Abstract
The actin binding protein Mammalian enabled (Mena), has been implicated in the metastatic progression of solid tumors in humans. Mena expression level in primary tumors is correlated with metastasis in breast, cervical, colorectal and pancreatic cancers. Cells expressing high Mena levels are part of the tumor microenvironment for metastasis (TMEM), an anatomical structure that is predictive for risk of breast cancer metastasis. Previously we have shown that forced expression of Mena adenocarcinoma cells enhances invasion and metastasis in xenograft mice. Whether Mena is required for tumor progression is still unknown. Here we report the effects of Mena deficiency on tumor progression, metastasis and on normal mammary gland development.
Original language | English |
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Pages (from-to) | R101 |
Journal | Breast Cancer Research |
Volume | 12 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2010 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Antigens, Polyomavirus Transforming
- Cytoskeletal Proteins
- Disease Progression
- Epidermal Growth Factor
- Female
- Gene Expression
- Lung Neoplasms
- Macrophages
- Mammary Glands, Animal
- Mammary Neoplasms, Experimental
- Mammary Tumor Virus, Mouse
- Mice
- Mice, SCID
- Mice, Transgenic
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Polymerase Chain Reaction
- Tumor Microenvironment