Meta-analysis of chicken-salmonella infection experiments

Marinus F W Te Pas, Ina Hulsegge, Dirkjan Schokker, Mari A Smits, Mark Fife, Rima Zoorob, Marie-Laure Endale, Johanna M J Rebel

Research output: Contribution to journalArticlepeer-review

Abstract

Chicken meat and eggs can be a source of human zoonotic pathogens, especially Salmonella species. These food items contain a potential hazard for humans. Chickens lines differ in susceptibility for Salmonella and can harbor Salmonella pathogens without showing clinical signs of illness. Many investigations including genomic studies have examined the mechanisms how chickens react to infection. Apart from the innate immune response, many physiological mechanisms and pathways are reported to be involved in the chicken host response to Salmonella infection. The objective of this study was to perform a meta-analysis of diverse experiments to identify general and host specific mechanisms to the Salmonella challenge.
Original languageEnglish
Article number146
JournalBMC Genomics
Volume13
DOIs
Publication statusPublished - 2012

Keywords

  • Animals
  • Cell Movement
  • Chickens
  • Computational Biology
  • Gene Expression Profiling
  • Oligonucleotide Array Sequence Analysis
  • Phosphorylation
  • Proteasome Endopeptidase Complex
  • Proteolysis
  • Salmonella
  • Salmonella Infections, Animal
  • Ubiquitin

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