Meta-analysis of genome-wide association for migraine in six population-based European cohorts

Lannie Ligthart, Boukje de Vries, Albert V Smith, M Arfan Ikram, Najaf Amin, Jouke-Jan Hottenga, Stephany C Koelewijn, V Mathijs Kattenberg, Marleen H M de Moor, A Cecile J W Janssens, Yurii S Aulchenko, Ben A Oostra, Eco J C de Geus, Johannes H Smit, Frans G Zitman, André G Uitterlinden, Albert Hofman, Gonneke Willemsen, Dale R Nyholt, Grant W MontgomeryGisela M Terwindt, Vilmundur Gudnason, Brenda W J H Penninx, Monique Breteler, Michel D Ferrari, Lenore J Launer, Cornelia M van Duijn, Arn M J M van den Maagdenberg, Dorret I Boomsma

Research output: Contribution to journalArticlepeer-review

Abstract

Migraine is a common neurological disorder with a genetically complex background. This paper describes a meta-analysis of genome-wide association (GWA) studies on migraine, performed by the Dutch-Icelandic migraine genetics (DICE) consortium, which brings together six population-based European migraine cohorts with a total sample size of 10,980 individuals (2446 cases and 8534 controls). A total of 32 SNPs showed marginal evidence for association at a P-value
Original languageEnglish
Pages (from-to)901-7
Number of pages7
JournalEuropean Journal of Human Genetics
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Cell Adhesion Molecules
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Glutamic Acid
  • Iceland
  • Migraine Disorders
  • Nerve Tissue Proteins
  • Netherlands
  • Polymorphism, Single Nucleotide
  • Receptors, Nerve Growth Factor

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