Meta-analysis of genome-wide association studies for extraversion: Findings from the Genetics of Personality Consortium

Generation Scotland; Stéphanie M van den Berg; Marleen H M de Moor; Karin J H Verweij; Robert F Krueger; Michelle Luciano; Alejandro Arias Vasquez; Lindsay K Matteson; Jaime Derringer; Tõnu Esko; Najaf Amin; Scott D Gordon; Narelle K Hansell; Amy B Hart; Ilkka Seppälä; Jennifer E Huffman; Bettina Konte; Jari Lahti; Minyoung Lee; Mike Miller; Teresa Nutile; Toshiko Tanaka; Alexander Teumer; Alexander Viktorin; Juho Wedenoja; Abdel Abdellaoui; Goncalo R Abecasis; Daniel E Adkins; Arpana Agrawal; Jüri Allik; Katja Appel; Timothy B Bigdeli; Fabio Busonero; Harry Campbell; Paul T Costa; George Davey Smith; Gail Davies; Harriet de Wit; Jun Ding; Barbara E Engelhardt; Johan G Eriksson; Iryna O Fedko; David C Liewald; Ozren Polasek; John M Starr; Lina Zgaga; David Porteous; Caroline Hayward; Igor Rudan; Ian J Deary; James F Wilson

doi:10.1007/s10519-015-9735-5

Meta-analysis of genome-wide association studies for extraversion: Findings from the Genetics of Personality Consortium

Generation Scotland, Stéphanie M van den Berg, Marleen H M de Moor, Karin J H Verweij, Robert F Krueger, Michelle Luciano, Alejandro Arias Vasquez, Lindsay K Matteson, Jaime Derringer, Tõnu Esko, Najaf Amin, Scott D Gordon, Narelle K Hansell, Amy B Hart, Ilkka Seppälä, Jennifer E Huffman, Bettina Konte, Jari Lahti, Minyoung Lee, Mike MillerTeresa Nutile, Toshiko Tanaka, Alexander Teumer, Alexander Viktorin, Juho Wedenoja, Abdel Abdellaoui, Goncalo R Abecasis, Daniel E Adkins, Arpana Agrawal, Jüri Allik, Katja Appel, Timothy B Bigdeli, Fabio Busonero, Harry Campbell, Paul T Costa, George Davey Smith, Gail Davies, Harriet de Wit, Jun Ding, Barbara E Engelhardt, Johan G Eriksson, Iryna O Fedko, David C Liewald, Ozren Polasek, John M Starr, Lina Zgaga, David Porteous, Caroline Hayward, Igor Rudan, Ian J Deary, James F Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.

Original language	English
Number of pages	13
Journal	Behavior Genetics
Early online date	11 Sept 2015
DOIs	https://doi.org/10.1007/s10519-015-9735-5
Publication status	E-pub ahead of print - 11 Sept 2015

Keywords / Materials (for Non-textual outputs)

Personality
Polygenic risk
Imputation
Phenotype harmonization
Common genetic variants

Access to Document

10.1007/s10519-015-9735-5

Luciano-etal-BG-2015-Meta-analysis-of-Genome-Wide-Association-Studies-for-ExtraversionFinal published version, 701 KBLicence: Creative Commons: Attribution (CC-BY)

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
A Hundred at Ninety: the common cause Hypothesis of Ageing tested in four waves of the Lothian Birth Cohort 1921
Deary, I., Bates, T., Gow, A. & Starr, J.
UK central government bodies/local authorities, health and hospital authorities
1/01/11 → 31/12/12
Project: Research
A genome wide association study of non pathological cognitive ageing
Deary, I., Porteous, D. & Tenesa, A.
BBSRC
1/09/08 → 31/08/10
Project: Research

Cite this

Generation Scotland, van den Berg, S. M., de Moor, M. H. M., Verweij, K. J. H., Krueger, R. F., Luciano, M., Arias Vasquez, A., Matteson, L. K., Derringer, J., Esko, T., Amin, N., Gordon, S. D., Hansell, N. K., Hart, A. B., Seppälä, I., Huffman, J. E., Konte, B., Lahti, J., Lee, M., ... Wilson, J. F. (2015). Meta-analysis of genome-wide association studies for extraversion: Findings from the Genetics of Personality Consortium. Behavior Genetics. Advance online publication. https://doi.org/10.1007/s10519-015-9735-5

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title = "Meta-analysis of genome-wide association studies for extraversion: Findings from the Genetics of Personality Consortium",

abstract = "Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.",

keywords = "Personality, Polygenic risk, Imputation, Phenotype harmonization, Common genetic variants ",

author = "{Generation Scotland} and {van den Berg}, {St{\'e}phanie M} and {de Moor}, {Marleen H M} and Verweij, {Karin J H} and Krueger, {Robert F} and Michelle Luciano and {Arias Vasquez}, Alejandro and Matteson, {Lindsay K} and Jaime Derringer and T{\~o}nu Esko and Najaf Amin and Gordon, {Scott D} and Hansell, {Narelle K} and Hart, {Amy B} and Ilkka Sepp{\"a}l{\"a} and Huffman, {Jennifer E} and Bettina Konte and Jari Lahti and Minyoung Lee and Mike Miller and Teresa Nutile and Toshiko Tanaka and Alexander Teumer and Alexander Viktorin and Juho Wedenoja and Abdel Abdellaoui and Abecasis, {Goncalo R} and Adkins, {Daniel E} and Arpana Agrawal and J{\"u}ri Allik and Katja Appel and Bigdeli, {Timothy B} and Fabio Busonero and Harry Campbell and Costa, {Paul T} and Smith, {George Davey} and Gail Davies and {de Wit}, Harriet and Jun Ding and Engelhardt, {Barbara E} and Eriksson, {Johan G} and Fedko, {Iryna O} and Liewald, {David C} and Ozren Polasek and Starr, {John M} and Lina Zgaga and David Porteous and Caroline Hayward and Igor Rudan and Deary, {Ian J} and Wilson, {James F}",

year = "2015",

month = sep,

day = "11",

doi = "10.1007/s10519-015-9735-5",

language = "English",

journal = "Behavior Genetics",

issn = "0001-8244",

publisher = "Springer",

}

Generation Scotland, van den Berg, SM, de Moor, MHM, Verweij, KJH, Krueger, RF, Luciano, M, Arias Vasquez, A, Matteson, LK, Derringer, J, Esko, T, Amin, N, Gordon, SD, Hansell, NK, Hart, AB, Seppälä, I, Huffman, JE, Konte, B, Lahti, J, Lee, M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, GR, Adkins, DE, Agrawal, A, Allik, J, Appel, K, Bigdeli, TB, Busonero, F, Campbell, H, Costa, PT, Smith, GD, Davies, G, de Wit, H, Ding, J, Engelhardt, BE, Eriksson, JG, Fedko, IO, Liewald, DC, Polasek, O, Starr, JM, Zgaga, L, Porteous, D, Hayward, C , Rudan, I , Deary, IJ & Wilson, JF 2015, 'Meta-analysis of genome-wide association studies for extraversion: Findings from the Genetics of Personality Consortium', Behavior Genetics. https://doi.org/10.1007/s10519-015-9735-5

TY - JOUR

T1 - Meta-analysis of genome-wide association studies for extraversion

T2 - Findings from the Genetics of Personality Consortium

AU - Generation Scotland

AU - van den Berg, Stéphanie M

AU - de Moor, Marleen H M

AU - Verweij, Karin J H

AU - Krueger, Robert F

AU - Luciano, Michelle

AU - Arias Vasquez, Alejandro

AU - Matteson, Lindsay K

AU - Derringer, Jaime

AU - Esko, Tõnu

AU - Amin, Najaf

AU - Gordon, Scott D

AU - Hansell, Narelle K

AU - Hart, Amy B

AU - Seppälä, Ilkka

AU - Huffman, Jennifer E

AU - Konte, Bettina

AU - Lahti, Jari

AU - Lee, Minyoung

AU - Miller, Mike

AU - Nutile, Teresa

AU - Tanaka, Toshiko

AU - Teumer, Alexander

AU - Viktorin, Alexander

AU - Wedenoja, Juho

AU - Abdellaoui, Abdel

AU - Abecasis, Goncalo R

AU - Adkins, Daniel E

AU - Agrawal, Arpana

AU - Allik, Jüri

AU - Appel, Katja

AU - Bigdeli, Timothy B

AU - Busonero, Fabio

AU - Campbell, Harry

AU - Costa, Paul T

AU - Smith, George Davey

AU - Davies, Gail

AU - de Wit, Harriet

AU - Ding, Jun

AU - Engelhardt, Barbara E

AU - Eriksson, Johan G

AU - Fedko, Iryna O

AU - Liewald, David C

AU - Polasek, Ozren

AU - Starr, John M

AU - Zgaga, Lina

AU - Porteous, David

AU - Hayward, Caroline

AU - Rudan, Igor

AU - Deary, Ian J

AU - Wilson, James F

PY - 2015/9/11

Y1 - 2015/9/11

N2 - Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.

AB - Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.

KW - Personality

KW - Polygenic risk

KW - Imputation

KW - Phenotype harmonization

KW - Common genetic variants

U2 - 10.1007/s10519-015-9735-5

DO - 10.1007/s10519-015-9735-5

M3 - Article

C2 - 26362575

SN - 0001-8244

JO - Behavior Genetics

JF - Behavior Genetics

ER -

Meta-analysis of genome-wide association studies for extraversion: Findings from the Genetics of Personality Consortium

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

A Hundred at Ninety: the common cause Hypothesis of Ageing tested in four waves of the Lothian Birth Cohort 1921

A genome wide association study of non pathological cognitive ageing

Cite this