Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

Marta F. Nabais; Simon M. Laws; Tian Lin; Costanza L. Vallerga; Nicola J. Armstrong; Ian P. Blair; John B. Kwok; Karen A. Mather; George D. Mellick; Perminder S. Sachdev; Leanne Wallace; Anjali K. Henders; Ramona A. J. Zwamborn; Paul J. Hop; Katie Lunnon; Ehsan Pishva; Janou A. Y. Roubroeks; Hilkka Soininen; Magda Tsolaki; Patrizia Mecocci; Simon Lovestone; Iwona Kłoszewska; Bruno Vellas; Sarah Furlong; Fleur C. Garton; Robert D. Henderson; Susan Mathers; Pamela A. Mccombe; Merrilee Needham; Shyuan T. Ngo; Garth Nicholson; Roger Pamphlett; Dominic B. Rowe; Frederik J. Steyn; Kelly L. Williams; Tim J. Anderson; Steven R. Bentley; John Dalrymple-alford; Javed Fowder; Jacob Gratten; Glenda Halliday; Ian B. Hickie; Martin Kennedy; Simon J. G. Lewis; Grant W. Montgomery; John Pearson; Toni L. Pitcher; Peter Silburn; Futao Zhang; Peter M. Visscher; Jian Yang; Anna J. Stevenson; Robert F. Hillary; Riccardo E. Marioni; Sarah E. Harris; Ian J. Deary; Ashley R. Jones; Aleksey Shatunov; Alfredo Iacoangeli; Wouter Van Rheenen; Leonard H. Van Den Berg; Pamela J. Shaw; Cristopher E. Shaw; Karen E. Morrison; Ammar Al-chalabi; Jan H. Veldink; Eilis Hannon; Jonathan Mill; Naomi R. Wray; Allan F. Mcrae

doi:10.1186/s13059-021-02275-5

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

Marta F. Nabais, Simon M. Laws, Tian Lin, Costanza L. Vallerga, Nicola J. Armstrong, Ian P. Blair, John B. Kwok, Karen A. Mather, George D. Mellick, Perminder S. Sachdev, Leanne Wallace, Anjali K. Henders, Ramona A. J. Zwamborn, Paul J. Hop, Katie Lunnon, Ehsan Pishva, Janou A. Y. Roubroeks, Hilkka Soininen, Magda Tsolaki, Patrizia MecocciSimon Lovestone, Iwona Kłoszewska, Bruno Vellas, Sarah Furlong, Fleur C. Garton, Robert D. Henderson, Susan Mathers, Pamela A. Mccombe, Merrilee Needham, Shyuan T. Ngo, Garth Nicholson, Roger Pamphlett, Dominic B. Rowe, Frederik J. Steyn, Kelly L. Williams, Tim J. Anderson, Steven R. Bentley, John Dalrymple-alford, Javed Fowder, Jacob Gratten, Glenda Halliday, Ian B. Hickie, Martin Kennedy, Simon J. G. Lewis, Grant W. Montgomery, John Pearson, Toni L. Pitcher, Peter Silburn, Futao Zhang, Peter M. Visscher, Jian Yang, Anna J. Stevenson, Robert F. Hillary, Riccardo E. Marioni, Sarah E. Harris, Ian J. Deary, Ashley R. Jones, Aleksey Shatunov, Alfredo Iacoangeli, Wouter Van Rheenen, Leonard H. Van Den Berg, Pamela J. Shaw, Cristopher E. Shaw, Karen E. Morrison, Ammar Al-chalabi, Jan H. Veldink, Eilis Hannon, Jonathan Mill, Naomi R. Wray, Allan F. Mcrae

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Genome Biology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s13059-021-02275-5
Publication status	Published - 26 Mar 2021

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10.1186/s13059-021-02275-5Licence: CC BY

s13059-021-02275-5Final published version, 2.12 MBLicence: Creative Commons: Attribution (CC-BY)

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-021-02275-5

1 Doctoral Thesis

A multi–omics approach to understand the role of plasma proteins in cognitive ageing and dementia
Hillary, R., 2021
Research output: Thesis › Doctoral Thesis

Cite this

Nabais, M. F., Laws, S. M., Lin, T., Vallerga, C. L., Armstrong, N. J., Blair, I. P., Kwok, J. B., Mather, K. A., Mellick, G. D., Sachdev, P. S., Wallace, L., Henders, A. K., Zwamborn, R. A. J., Hop, P. J., Lunnon, K., Pishva, E., Roubroeks, J. A. Y., Soininen, H., Tsolaki, M., ... Mcrae, A. F. (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biology, 22(1). https://doi.org/10.1186/s13059-021-02275-5

@article{b01e1278ca584dc79f58c601fd1416b5,

title = "Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders",

author = "Nabais, {Marta F.} and Laws, {Simon M.} and Tian Lin and Vallerga, {Costanza L.} and Armstrong, {Nicola J.} and Blair, {Ian P.} and Kwok, {John B.} and Mather, {Karen A.} and Mellick, {George D.} and Sachdev, {Perminder S.} and Leanne Wallace and Henders, {Anjali K.} and Zwamborn, {Ramona A. J.} and Hop, {Paul J.} and Katie Lunnon and Ehsan Pishva and Roubroeks, {Janou A. Y.} and Hilkka Soininen and Magda Tsolaki and Patrizia Mecocci and Simon Lovestone and Iwona K{\l}oszewska and Bruno Vellas and Sarah Furlong and Garton, {Fleur C.} and Henderson, {Robert D.} and Susan Mathers and Mccombe, {Pamela A.} and Merrilee Needham and Ngo, {Shyuan T.} and Garth Nicholson and Roger Pamphlett and Rowe, {Dominic B.} and Steyn, {Frederik J.} and Williams, {Kelly L.} and Anderson, {Tim J.} and Bentley, {Steven R.} and John Dalrymple-alford and Javed Fowder and Jacob Gratten and Glenda Halliday and Hickie, {Ian B.} and Martin Kennedy and Lewis, {Simon J. G.} and Montgomery, {Grant W.} and John Pearson and Pitcher, {Toni L.} and Peter Silburn and Futao Zhang and Visscher, {Peter M.} and Jian Yang and Stevenson, {Anna J.} and Hillary, {Robert F.} and Marioni, {Riccardo E.} and Harris, {Sarah E.} and Deary, {Ian J.} and Jones, {Ashley R.} and Aleksey Shatunov and Alfredo Iacoangeli and {Van Rheenen}, Wouter and {Van Den Berg}, {Leonard H.} and Shaw, {Pamela J.} and Shaw, {Cristopher E.} and Morrison, {Karen E.} and Ammar Al-chalabi and Veldink, {Jan H.} and Eilis Hannon and Jonathan Mill and Wray, {Naomi R.} and Mcrae, {Allan F.}",

note = "DP emailed corresponding author for manuscript 26/04/21 ",

year = "2021",

month = mar,

day = "26",

doi = "10.1186/s13059-021-02275-5",

language = "English",

volume = "22",

journal = "Genome Biology",

issn = "1465-6906",

publisher = "BioMed Central",

number = "1",

}

Nabais, MF, Laws, SM, Lin, T, Vallerga, CL, Armstrong, NJ, Blair, IP, Kwok, JB, Mather, KA, Mellick, GD, Sachdev, PS, Wallace, L, Henders, AK, Zwamborn, RAJ, Hop, PJ, Lunnon, K, Pishva, E, Roubroeks, JAY, Soininen, H, Tsolaki, M, Mecocci, P, Lovestone, S, Kłoszewska, I, Vellas, B, Furlong, S, Garton, FC, Henderson, RD, Mathers, S, Mccombe, PA, Needham, M, Ngo, ST, Nicholson, G, Pamphlett, R, Rowe, DB, Steyn, FJ, Williams, KL, Anderson, TJ, Bentley, SR, Dalrymple-alford, J, Fowder, J, Gratten, J, Halliday, G, Hickie, IB, Kennedy, M, Lewis, SJG, Montgomery, GW, Pearson, J, Pitcher, TL, Silburn, P, Zhang, F, Visscher, PM, Yang, J, Stevenson, AJ , Hillary, RF , Marioni, RE , Harris, SE , Deary, IJ, Jones, AR, Shatunov, A, Iacoangeli, A, Van Rheenen, W, Van Den Berg, LH, Shaw, PJ, Shaw, CE, Morrison, KE, Al-chalabi, A, Veldink, JH, Hannon, E, Mill, J, Wray, NR & Mcrae, AF 2021, 'Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders', Genome Biology, vol. 22, no. 1. https://doi.org/10.1186/s13059-021-02275-5

TY - JOUR

T1 - Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

AU - Nabais, Marta F.

AU - Laws, Simon M.

AU - Lin, Tian

AU - Vallerga, Costanza L.

AU - Armstrong, Nicola J.

AU - Blair, Ian P.

AU - Kwok, John B.

AU - Mather, Karen A.

AU - Mellick, George D.

AU - Sachdev, Perminder S.

AU - Wallace, Leanne

AU - Henders, Anjali K.

AU - Zwamborn, Ramona A. J.

AU - Hop, Paul J.

AU - Lunnon, Katie

AU - Pishva, Ehsan

AU - Roubroeks, Janou A. Y.

AU - Soininen, Hilkka

AU - Tsolaki, Magda

AU - Mecocci, Patrizia

AU - Lovestone, Simon

AU - Kłoszewska, Iwona

AU - Vellas, Bruno

AU - Furlong, Sarah

AU - Garton, Fleur C.

AU - Henderson, Robert D.

AU - Mathers, Susan

AU - Mccombe, Pamela A.

AU - Needham, Merrilee

AU - Ngo, Shyuan T.

AU - Nicholson, Garth

AU - Pamphlett, Roger

AU - Rowe, Dominic B.

AU - Steyn, Frederik J.

AU - Williams, Kelly L.

AU - Anderson, Tim J.

AU - Bentley, Steven R.

AU - Dalrymple-alford, John

AU - Fowder, Javed

AU - Gratten, Jacob

AU - Halliday, Glenda

AU - Hickie, Ian B.

AU - Kennedy, Martin

AU - Lewis, Simon J. G.

AU - Montgomery, Grant W.

AU - Pearson, John

AU - Pitcher, Toni L.

AU - Silburn, Peter

AU - Zhang, Futao

AU - Visscher, Peter M.

AU - Yang, Jian

AU - Stevenson, Anna J.

AU - Hillary, Robert F.

AU - Marioni, Riccardo E.

AU - Harris, Sarah E.

AU - Deary, Ian J.

AU - Jones, Ashley R.

AU - Shatunov, Aleksey

AU - Iacoangeli, Alfredo

AU - Van Rheenen, Wouter

AU - Van Den Berg, Leonard H.

AU - Shaw, Pamela J.

AU - Shaw, Cristopher E.

AU - Morrison, Karen E.

AU - Al-chalabi, Ammar

AU - Veldink, Jan H.

AU - Hannon, Eilis

AU - Mill, Jonathan

AU - Wray, Naomi R.

AU - Mcrae, Allan F.

N1 - DP emailed corresponding author for manuscript 26/04/21

PY - 2021/3/26

Y1 - 2021/3/26

U2 - 10.1186/s13059-021-02275-5

DO - 10.1186/s13059-021-02275-5

M3 - Article

VL - 22

JO - Genome Biology

JF - Genome Biology

SN - 1465-6906

IS - 1

ER -

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

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Research output

A multi–omics approach to understand the role of plasma proteins in cognitive ageing and dementia

Cite this