Metabolic modeling of microbial strains in silico

Markus W Covert, Christophe H Schilling, Iman Famili, Jeremy S Edwards, Igor I Goryanin, Evgeni Selkov, Bernhard O Palsson

Research output: Contribution to journalArticlepeer-review


The large volume of genome-scale data that is being produced and made available in databases on the World Wide Web is demanding the development of integrated mathematical models of cellular processes. The analysis of reconstructed metabolic networks as systems leads to the development of an in silico or computer representation of collections of cellular metabolic constituents, their interactions and their integrated function as a whole. The use of quantitative analysis methods to generate testable hypotheses and drive experimentation at a whole-genome level signals the advent of a systemic modeling approach to cellular and molecular biology.
Original languageEnglish
Pages (from-to)179-186
Number of pages8
JournalTrends in biochemical sciences
Issue number3
Publication statusPublished - 2001


Dive into the research topics of 'Metabolic modeling of microbial strains in silico'. Together they form a unique fingerprint.

Cite this