Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine

Laura E McNamara, Terje Sjöström, RM Dominic Meek, Richard OC Oreffo, Bo Su, Matthew J Dalby, Karl EV Burgess

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation. A particular focus is on the application of metabolomics to the study of stem cell physiology in the context of biomaterials and regenerative medicine. Case studies are used to illustrate key points, focusing on the use of metabolomics in the examination of mesenchymal stem cell responses to titania-nanopillared substrata designed for orthopaedic applications.
Original languageEnglish
Pages (from-to)1713-1724
Number of pages12
JournalJournal of the Royal Society. Interface
Issue number73
Early online date23 May 2012
Publication statusPublished - 7 Aug 2012

Keywords / Materials (for Non-textual outputs)

  • metabolomics
  • stem cells
  • biomaterials
  • mass spectrometry
  • regenerative medicine
  • titanium


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