Projects per year
Solution-phase spectroscopy and mass spectrometry are used to probe interactions between divalent metal ions and a synthetic Cys(2)His(2) zinc-finger peptide (vCP1). Both methods provide the same order of binding affinity, zinc >= cobalt >> copper >> calcium. Collision-cross-section measurements show that both apo and holo forms are compact. This is corroborated by molecular-dynamics simulations.
|Number of pages||3|
|Publication status||Published - 2011|
FingerprintDive into the research topics of 'Metal binding to a zinc-finger peptide: a comparison between solution and the gas phase'. Together they form a unique fingerprint.
- 2 Finished
The MoQToF: Development of an Ion Mobility Mass Spectrometer to Study Structure and Energetics of Proteins and Peptides
28/06/04 → 27/06/07
ARF: Structure and energetics of peptides and small proteins
1/03/03 → 31/07/08