Metal organic frameworks for antibacterial applications

Li Yan, Ashna Gopal, Saima Kashif, Patricia Hazelton, Minhuan Lan*, Wenjun Zhang, Xianfeng Chen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

The number of cases of bacterial resistance to antibiotics has been exponentially rising over the last decade. This issue is getting worse as the research and development of new antibiotics is much slower than the speed of pathogenic bacteria acquiring resistance to antibiotic treatment. To fight against antibacterial resistance, new therapeutic strategies have to be sought as alternatives to currently administered antibiotics. Many new materials, for instance, metal organic frameworks possess desirable properties such as improved bacterial internalization, flexible structural control, high selectivity, and controlled drug release and therefore, are potentially good candidates for antibacterial therapy to overcome antibiotic resistance. This review describes the most recent development of the field of the antibacterial applications of metal organic frameworks, and their hybrids and derivatives, followed by an in-depth analysis of their advantages, disadvantages and design factors of these materials. Finally, we present our insights into the important aspects of the future development of metal organic frameworks for antibacterial applications.

Original languageEnglish
Article number134975
JournalChemical Engineering Journal
Volume435
Issue numberPart 2
Early online date3 Feb 2022
DOIs
Publication statusPublished - 1 May 2022

Keywords / Materials (for Non-textual outputs)

  • Antibacterial therapy
  • Antibiotics
  • Antimicrobial resistance
  • Composite materials
  • Metal organic frameworks

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