Methicillin-resistance in Staphylococcus pseudintermedius encoded within novel staphylococcal cassette chromosome mec (SCCmec) variants: Novel SCCmec element in Staphylococcus pseudintermedius

Alison Macfadyen, Gavin Paterson

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background. Staphylococcus pseudintermedius is a common opportunistic pathogen of companion dogs and an occasional human pathogen. Treatment is hampered by antimicrobial resistance including methicillin-resistance encoded by mecA within the mobile genetic element SCCmec.
Objectives. SCCmec elements are diverse, especially in non-Staphyloccocus aureus staphylococci, and novel variants are likely to be present in S. pseudintermedius. The aim was to characterise the SCCmec elements found in four canine clinical isolates of S. pseudintermedius.
Methods. Isolates were whole-genome sequenced and SCCmec elements were assembled, annotated and compared to known SCCmec types.
Results. Two novel SSCmec are present in these isolates. SCCmec7017-61515 is characterised by a novel combination of a Class A mec gene complex and a type 5 ccr previously only described in composite SCCmec elements. The other three isolates share a novel composite SCCmec with features of SCCmec types IV and VI.
Conclusions. S. pseudintermedius is a reservoir of novel SSCmec elements which has implications for understanding antimicrobial resistant in veterinary and human medicine.
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Early online date2 Apr 2024
DOIs
Publication statusE-pub ahead of print - 2 Apr 2024

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