Methods to improve joint genetic evaluation of canine hip dysplasia across BVA/KC and FCI screening schemes

Shizhi Wang; Juliane Friedrich; Erling Strandberg; Per Arvelius; Pam Wiener

doi:10.3389/fvets.2020.00386

Methods to improve joint genetic evaluation of canine hip dysplasia across BVA/KC and FCI screening schemes

Shizhi Wang
, Juliane Friedrich
, Erling Strandberg
, Per Arvelius
, Pam Wiener

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

The BVA/KC (British Veterinary Association/Kennel Club) and FCI (Fédération Cynologique Internationale) are the main screening schemes used to evaluate the status of canine hip dysplasia
(HD) in Europe. Jointly utilizing HD records from both BVA/KC and FCI schemes could improve the
reliability of genetic evaluation within and across countries. In this study, HD scores for German shepherd dogs (GSDs) in the UK (using the BVA/KC scheme) and Sweden (using the FCI scheme) were used to investigate how to better operate joint genetic evaluations across the two schemes. It was shown that under a bivariate model, which regarded BVA/KC and FCI scores as different traits, the estimated genetic correlations between the UK and Swedish GSD populations were the same when using BVA/KC total or worse hip scores and for single-country or joint analysis of both the UK and Swedish populations. Under a univariate model that converted BVA/KC scores into FCI scores, the predictability of estimated breeding values was slightly improved by performing a joint analysis.

Original language	English
Journal	Frontiers in Veterinary Science
Early online date	11 Aug 2020
DOIs	https://doi.org/10.3389/fvets.2020.00386
Publication status	E-pub ahead of print - 11 Aug 2020

Keywords / Materials (for Non-textual outputs)

Best linear unbiased prediction
Estimated breeding value,
Genetic correlation
Genetic evaluation
Hip dysplasia

Access to Document

10.3389/fvets.2020.00386

fvets-07-00386Final published version, 489 KBLicence: Creative Commons: Attribution (CC-BY)

UK dogs data from: Genome-wide association studies for canine hip dysplasia in single and multiple populations – implications and potential novel risk loci
Friedrich, J. (Creator), Wang, S. (Creator), Strandberg, E. (Creator), Arvelius, P. (Creator), Clements, D. N. (Creator) & Wiener, P. (Creator), Dryad, 13 Aug 2021
DOI: 10.5061/dryad.h44j0zpkf, https://datadryad.org/dataset/doi:10.5061/dryad.h44j0zpkf and one more link, https://zenodo.org/records/5197610 (show fewer)
Dataset

Cite this

@article{57d5e7e74bfa4f8da41c8d35c5e91be4,

title = "Methods to improve joint genetic evaluation of canine hip dysplasia across BVA/KC and FCI screening schemes",

abstract = "The BVA/KC (British Veterinary Association/Kennel Club) and FCI (F{\'e}d{\'e}ration Cynologique Internationale) are the main screening schemes used to evaluate the status of canine hip dysplasia (HD) in Europe. Jointly utilizing HD records from both BVA/KC and FCI schemes could improve the reliability of genetic evaluation within and across countries. In this study, HD scores for German shepherd dogs (GSDs) in the UK (using the BVA/KC scheme) and Sweden (using the FCI scheme) were used to investigate how to better operate joint genetic evaluations across the two schemes. It was shown that under a bivariate model, which regarded BVA/KC and FCI scores as different traits, the estimated genetic correlations between the UK and Swedish GSD populations were the same when using BVA/KC total or worse hip scores and for single-country or joint analysis of both the UK and Swedish populations. Under a univariate model that converted BVA/KC scores into FCI scores, the predictability of estimated breeding values was slightly improved by performing a joint analysis.",

keywords = "Best linear unbiased prediction, Estimated breeding value,, Genetic correlation, Genetic evaluation, Hip dysplasia",

author = "Shizhi Wang and Juliane Friedrich and Erling Strandberg and Per Arvelius and Pam Wiener",

year = "2020",

month = aug,

day = "11",

doi = "10.3389/fvets.2020.00386",

language = "English",

journal = "Frontiers in Veterinary Science",

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TY - JOUR

T1 - Methods to improve joint genetic evaluation of canine hip dysplasia across BVA/KC and FCI screening schemes

AU - Wang, Shizhi

AU - Friedrich, Juliane

AU - Strandberg , Erling

AU - Arvelius , Per

AU - Wiener, Pam

PY - 2020/8/11

Y1 - 2020/8/11

N2 - The BVA/KC (British Veterinary Association/Kennel Club) and FCI (Fédération Cynologique Internationale) are the main screening schemes used to evaluate the status of canine hip dysplasia (HD) in Europe. Jointly utilizing HD records from both BVA/KC and FCI schemes could improve the reliability of genetic evaluation within and across countries. In this study, HD scores for German shepherd dogs (GSDs) in the UK (using the BVA/KC scheme) and Sweden (using the FCI scheme) were used to investigate how to better operate joint genetic evaluations across the two schemes. It was shown that under a bivariate model, which regarded BVA/KC and FCI scores as different traits, the estimated genetic correlations between the UK and Swedish GSD populations were the same when using BVA/KC total or worse hip scores and for single-country or joint analysis of both the UK and Swedish populations. Under a univariate model that converted BVA/KC scores into FCI scores, the predictability of estimated breeding values was slightly improved by performing a joint analysis.

AB - The BVA/KC (British Veterinary Association/Kennel Club) and FCI (Fédération Cynologique Internationale) are the main screening schemes used to evaluate the status of canine hip dysplasia (HD) in Europe. Jointly utilizing HD records from both BVA/KC and FCI schemes could improve the reliability of genetic evaluation within and across countries. In this study, HD scores for German shepherd dogs (GSDs) in the UK (using the BVA/KC scheme) and Sweden (using the FCI scheme) were used to investigate how to better operate joint genetic evaluations across the two schemes. It was shown that under a bivariate model, which regarded BVA/KC and FCI scores as different traits, the estimated genetic correlations between the UK and Swedish GSD populations were the same when using BVA/KC total or worse hip scores and for single-country or joint analysis of both the UK and Swedish populations. Under a univariate model that converted BVA/KC scores into FCI scores, the predictability of estimated breeding values was slightly improved by performing a joint analysis.

KW - Best linear unbiased prediction

KW - Estimated breeding value,

KW - Genetic correlation

KW - Genetic evaluation

KW - Hip dysplasia

U2 - 10.3389/fvets.2020.00386

DO - 10.3389/fvets.2020.00386

M3 - Article

SN - 2297-1769

JO - Frontiers in Veterinary Science

JF - Frontiers in Veterinary Science

ER -

Methods to improve joint genetic evaluation of canine hip dysplasia across BVA/KC and FCI screening schemes

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

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Datasets

UK dogs data from: Genome-wide association studies for canine hip dysplasia in single and multiple populations – implications and potential novel risk loci

Cite this