Micro- and Nanotechnologies for Intracellular Delivery

Li Yan, Jinfeng Zhang, Chun-Sing Lee, Xianfeng Chen

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The majority of drugs and biomolecules need to be delivered into cells to be effective. However, the cell membranes, a biological barrier, strictly resist drugs or biomolecules entering cells, resulting in significantly reduced intracellular delivery efficiency. To overcome this barrier, a variety of intracellular delivery approaches including chemical and physical ways have been developed in recent years. In this review, the focus is on summarizing the nanomaterial routes involved in making use of a collection of receptors for the targeted delivery of drugs and biomolecules and the physical ways of applying micro- and nanotechnologies for high-throughput intracellular delivery.
Original languageEnglish
Pages (from-to)4487-4504
JournalSmall
Volume10
Issue number22
Publication statusPublished - 26 Nov 2014

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