Microarray platforms for enzymatic and cell-based assays

Juan J. Diaz-Mochon; Guilhem Tourniaire; Mark Bradley

doi:10.1039/b511848b

Microarray platforms for enzymatic and cell-based assays

Juan J. Diaz-Mochon, Guilhem Tourniaire, Mark Bradley

Research output: Contribution to journal › Literature review › peer-review

Abstract

This tutorial review introduces the uninitiated to the world of microarrays (or so-called chips) and covers a number of basic concepts such as substrates and surfaces, printing and analysis. It then moves on to look at some newer applications of microarray technology, which include enzyme analysis (notably kinases and proteases) as well as the growing enchantment with so-called cell-based microarrays that offer a unique approach to high-throughput cellular analysis. Finally, it looks forwards and highlights future possible trends and directions in the microarray arena.

Original language	English
Pages (from-to)	449-457
Number of pages	9
Journal	Chemical Society Reviews
Volume	36
Issue number	3
DOIs	https://doi.org/10.1039/b511848b
Publication status	Published - 2007

Keywords / Materials (for Non-textual outputs)

EMBRYONIC STEM-CELLS
SUBSTRATE-SPECIFICITY
PEPTIDE MICROARRAYS
PROTEIN MICROARRAYS
KINASE-ACTIVITY
ARRAY
DNA
DIFFERENTIATION
IDENTIFICATION
TECHNOLOGY

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10.1039/b511848b

Interfacing DNA arrays and combinatorial libraries for high-content enzymatic screening
Bradley, M. (Principal Investigator)
Biotechnology and Biological Sciences Research Council
1/03/05 → 31/05/05
Project: Research

Cite this

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title = "Microarray platforms for enzymatic and cell-based assays",

abstract = "This tutorial review introduces the uninitiated to the world of microarrays (or so-called chips) and covers a number of basic concepts such as substrates and surfaces, printing and analysis. It then moves on to look at some newer applications of microarray technology, which include enzyme analysis (notably kinases and proteases) as well as the growing enchantment with so-called cell-based microarrays that offer a unique approach to high-throughput cellular analysis. Finally, it looks forwards and highlights future possible trends and directions in the microarray arena.",

keywords = "EMBRYONIC STEM-CELLS, SUBSTRATE-SPECIFICITY, PEPTIDE MICROARRAYS, PROTEIN MICROARRAYS, KINASE-ACTIVITY, ARRAY, DNA, DIFFERENTIATION, IDENTIFICATION, TECHNOLOGY",

author = "Diaz-Mochon, \{Juan J.\} and Guilhem Tourniaire and Mark Bradley",

year = "2007",

doi = "10.1039/b511848b",

language = "English",

volume = "36",

pages = "449--457",

journal = "Chemical Society Reviews",

issn = "0306-0012",

publisher = "Royal Society of Chemistry",

number = "3",

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T1 - Microarray platforms for enzymatic and cell-based assays

AU - Diaz-Mochon, Juan J.

AU - Tourniaire, Guilhem

AU - Bradley, Mark

PY - 2007

Y1 - 2007

N2 - This tutorial review introduces the uninitiated to the world of microarrays (or so-called chips) and covers a number of basic concepts such as substrates and surfaces, printing and analysis. It then moves on to look at some newer applications of microarray technology, which include enzyme analysis (notably kinases and proteases) as well as the growing enchantment with so-called cell-based microarrays that offer a unique approach to high-throughput cellular analysis. Finally, it looks forwards and highlights future possible trends and directions in the microarray arena.

AB - This tutorial review introduces the uninitiated to the world of microarrays (or so-called chips) and covers a number of basic concepts such as substrates and surfaces, printing and analysis. It then moves on to look at some newer applications of microarray technology, which include enzyme analysis (notably kinases and proteases) as well as the growing enchantment with so-called cell-based microarrays that offer a unique approach to high-throughput cellular analysis. Finally, it looks forwards and highlights future possible trends and directions in the microarray arena.

KW - EMBRYONIC STEM-CELLS

KW - SUBSTRATE-SPECIFICITY

KW - PEPTIDE MICROARRAYS

KW - PROTEIN MICROARRAYS

KW - KINASE-ACTIVITY

KW - ARRAY

KW - DNA

KW - DIFFERENTIATION

KW - IDENTIFICATION

KW - TECHNOLOGY

U2 - 10.1039/b511848b

DO - 10.1039/b511848b

M3 - Literature review

SN - 0306-0012

VL - 36

SP - 449

EP - 457

JO - Chemical Society Reviews

JF - Chemical Society Reviews

IS - 3

ER -

Microarray platforms for enzymatic and cell-based assays

Abstract

Keywords / Materials (for Non-textual outputs)

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Interfacing DNA arrays and combinatorial libraries for high-content enzymatic screening

Cite this