Microbe Profile: Escherichia coli O157 : H7 - notorious relative of the microbiologist's workhorse

Research output: Contribution to journalArticlepeer-review

Abstract

Escherichia coli O157 : H7 is a zoonotic diarrhoeal pathogen of worldwide importance. It belongs to a subset of Shiga toxin-producing E. coli that can form attaching and effacing lesions on intestinal epithelia via the action of a type 3 secretion system that injects bacterial effectors into enterocytes. Infections in humans often arise from contaminated food or direct environmental exposure and can involve life-threatening Shiga toxin-dependent sequelae. In the three decades since E. coli O157 : H7 was first recognized intensive research has helped to unravel the basis of pathogenesis, but few effective options for prevention and treatment of infections exist.
Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalMicrobiology
Volume163
Issue number1
DOIs
Publication statusPublished - 20 Feb 2017

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