Microbe Profile: Escherichia coli O157 : H7 - notorious relative of the microbiologist's workhorse

David L Gally; Mark P Stevens

doi:10.1099/mic.0.000387

Microbe Profile: Escherichia coli O157 : H7 - notorious relative of the microbiologist's workhorse

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Escherichia coli O157 : H7 is a zoonotic diarrhoeal pathogen of worldwide importance. It belongs to a subset of Shiga toxin-producing E. coli that can form attaching and effacing lesions on intestinal epithelia via the action of a type 3 secretion system that injects bacterial effectors into enterocytes. Infections in humans often arise from contaminated food or direct environmental exposure and can involve life-threatening Shiga toxin-dependent sequelae. In the three decades since E. coli O157 : H7 was first recognized intensive research has helped to unravel the basis of pathogenesis, but few effective options for prevention and treatment of infections exist.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Microbiology
Volume	163
Issue number	1
DOIs	https://doi.org/10.1099/mic.0.000387
Publication status	Published - 20 Feb 2017

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10.1099/mic.0.000387

Microbe Profile: Escherichia coli O157 : H7 – notorious relative of the microbiologist’s workhorse
©2017 The Authors This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Final published version, 750 KBLicence: Creative Commons: Attribution (CC-BY)

Innate immunity and endemic diseases in livestock species
Collie, D., Beard, P., Bishop, S., Bronsvoort, M., Burt, D., Fitzgerald, R., Freeman, T., Gally, D., Gill, A., Glass, E., Hocking, P., Hope, J., Hume, D., Kaiser, P., Mabbott, N., McLachlan, G., Morrison, L., Stevens, J., Stevens, M. & Watson, M.
BBSRC
1/04/12 → 31/03/17
Project: Research

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abstract = "Escherichia coli O157 : H7 is a zoonotic diarrhoeal pathogen of worldwide importance. It belongs to a subset of Shiga toxin-producing E. coli that can form attaching and effacing lesions on intestinal epithelia via the action of a type 3 secretion system that injects bacterial effectors into enterocytes. Infections in humans often arise from contaminated food or direct environmental exposure and can involve life-threatening Shiga toxin-dependent sequelae. In the three decades since E. coli O157 : H7 was first recognized intensive research has helped to unravel the basis of pathogenesis, but few effective options for prevention and treatment of infections exist.",

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Microbe Profile: Escherichia coli O157 : H7 - notorious relative of the microbiologist's workhorse

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Innate immunity and endemic diseases in livestock species

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