Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences

Roos-marijn Berbers, Stefan Nierkens, Jacob M. Van Laar, Debby Bogaert, Helen L. Leavis

Research output: Contribution to journalReview articlepeer-review


Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic immune dysregulation. Here, we critically review the current evidence for a role of the microbiome in the pathogenesis of CVID immune dysregulation, and describe the possible immunologic mechanisms behind causes and consequences of microbial dysbiosis in CVID. We integrate this evidence into a model describing a role for the gut microbiota in the maintenance of inflammation and immune dysregulation in CVID, and suggest research strategies to contribute to the development of new diagnostic tools and therapeutic targets.
Original languageEnglish
Pages (from-to)206-216
JournalTrends in Immunology
Issue number3
Early online date22 Dec 2016
Publication statusPublished - Mar 2017

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