Microbial Stimulation Reverses the Age-Related Decline in M Cells in Aged Mice

Research output: Contribution to journalArticlepeer-review

Abstract

Ageing has a profound effect on the immune system, termed immunosenescence, resulting in increased incidence and severity of infections and decreased efficacy of vaccinations. We previously showed that immunosurveillance in the intestine, achieved primarily through antigen sampling M cells in the follicle associated epithelium (FAE) of Peyer’s patches, was compromised during ageing due to a decline in M cell functional maturation. The intestinal microbiota also changes significantly with age, but whether this affects M cell maturation was not known. We show that housing of aged mice on used bedding from young mice, or treatment with bacterial flagellin, were each sufficient to enhance the functional maturation of M cells in Peyer’s
patches. An understanding of the mechanisms underlying the influence of the
intestinal microbiota on M cells has the potential to lead to new methods to enhance he efficacy of oral vaccination in aged individuals
Original languageEnglish
Article number101147
Pages (from-to)1-19
Number of pages19
JournaliScience
Volume23
Issue number6
Early online date11 May 2020
DOIs
Publication statusPublished - 26 Jun 2020

Keywords

  • M cells
  • Peyer’s patches
  • small intestine
  • mucosal immunity
  • ageing
  • microbiota
  • flagellin
  • IgA

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