Microbiological characteristics of acute osteoarticular infections in children

Clark D Russell, Rishi Ramaesh, Pota Kalima, Alastair Murray, Mark S Gaston

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to describe the microbiological characteristics of acute septic arthritis (SA) and osteomyelitis (OM) in children. Cases of children (0-15 years) with SA/OM were identified through a retrospective search of hospital discharge codes over a six-year period. In addition, a systematic literature search and meta-analysis of studies reporting culture results of children with SA/OM was performed. In our retrospective chart review, we identified 65 cases of OM and 46 cases of SA. The most frequently cultured organisms in both conditions were Gram-positive cocci, primarily Staphylococcus aureus. On admission, most patients had a normal white blood cell count (WCC) but elevated C-reactive protein (CRP) and/or erythrocyte sedimentation rate (ESR). Bacteraemia was associated with a longer mean length of hospitalization for both infections. Considering our results and the meta-analysis, we found low rates of culture-positivity in cases of clinically confirmed infection. In SA, articular fluid was culture-positive in 42.49% [95% confidence interval (CI) 28.39-57.23]. In OM, intra-operative samples were culture-positive in 52.65% (95% CI 30.54-74.22). Bacteraemia was detected in 23.91% (95% CI 8.40-44.24) of children with SA and 21.48% (95% CI 10.89-34.47) with OM. Despite appropriate sampling, a positive microbiological diagnosis is often lacking in paediatric acute osteoarticular infection using standard culture-based methods. This highlights the need for validation and use of more sensitive diagnostic methods, such as PCR.

Original languageEnglish
Pages (from-to)446-53
Number of pages8
JournalJournal of Medical Microbiology
Volume64
Issue numberPt 4
DOIs
Publication statusPublished - Apr 2015

Keywords

  • Adolescent
  • Arthritis, Infectious
  • Bacteremia
  • Bacteria
  • Bacterial Infections
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Osteomyelitis
  • Retrospective Studies
  • Journal Article
  • Meta-Analysis

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