Microfluidic technology for molecular diagnostics

Tom Robinson, Petra S. Dittrich

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Molecular diagnostics have helped to improve the lives of millions of patients worldwide by allowing clinicians to diagnose patients earlier as well as providing better ongoing therapies. Point-of-care (POC) testing can bring these laboratory-based techniques to the patient in a home setting or to remote settings in the developing world. However, despite substantial progress in the field, there still remain many challenges. Progress in molecular diagnostics has benefitted greatly from microfluidic technology. This chapter aims to summarise the more recent advances in microfluidic-based molecular diagnostics. Sections include an introduction to microfluidic technology, the challenges of molecular diagnostics, how microfluidic advances are working to solve these issues, some alternative design approaches, and detection within these systems.

Original languageEnglish
Title of host publicationMolecular Diagnostics
EditorsHarald Seitz, Sarah Schumacher
PublisherSpringer
Pages89-114
Number of pages26
ISBN (Print)9783642376900
DOIs
Publication statusPublished - 5 Aug 2012

Publication series

NameAdvances in Biochemical Engineering/Biotechnology
Volume133
ISSN (Print)0724-6145

Keywords / Materials (for Non-textual outputs)

  • Detection
  • Immunoassays
  • Lab-on-a-chip
  • Label-free
  • Lensless
  • Microfluidics
  • Paper-microfluidics
  • Pre-treatment

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