MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia

Gaia Spinetti; Orazio Fortunato; Andrea Caporali; Saran Shantikumar; Micol Marchetti; Marco Meloni; Betty Descamps; Ilaria Floris; Elena Sangalli; Rosa Vono; Ezio Faglia; Claudia Specchia; Gianfranco Pintus; Paolo Madeddu; Costanza Emanueli

doi:10.1161/CIRCRESAHA.111.300418

MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia

Gaia Spinetti, Orazio Fortunato, Andrea Caporali, Saran Shantikumar, Micol Marchetti, Marco Meloni, Betty Descamps, Ilaria Floris, Elena Sangalli, Rosa Vono, Ezio Faglia, Claudia Specchia, Gianfranco Pintus, Paolo Madeddu, Costanza Emanueli

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Circulating proangiogenic cells (PACs) support postischemic neovascularization. Cardiovascular disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that are not fully known. We hypothesize a role for microRNAs (miRs). Circulating miRs are currently investigated as potential diagnostic and prognostic biomarkers.

Original language	English
Pages (from-to)	335-46
Number of pages	12
Journal	Circulation Research
Volume	112
Issue number	2
DOIs	https://doi.org/10.1161/CIRCRESAHA.111.300418
Publication status	Published - 18 Jan 2013

Keywords / Materials (for Non-textual outputs)

Animals
Cell Movement
Cell Survival
Cell Transplantation
Cells, Cultured
Diabetes Complications
Diabetes Mellitus, Type 2
HEK293 Cells
Hindlimb
Humans
Ischemia
Mice
Mice, Nude
MicroRNAs
Neovascularization, Pathologic

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10.1161/CIRCRESAHA.111.300418

MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia.
© 2013 American Heart Association, Inc.
Accepted author manuscript, 3.9 MB

http://circres.ahajournals.org/content/112/2/335

Inter-cellular trafficking and regulation of microRNA-503 expression in diabetes induced microvascular complications
Caporali, A.
UK-based charities
1/09/13 → 28/02/17
Project: Research

Cite this

Spinetti, G., Fortunato, O., Caporali, A., Shantikumar, S., Marchetti, M., Meloni, M., Descamps, B., Floris, I., Sangalli, E., Vono, R., Faglia, E., Specchia, C., Pintus, G., Madeddu, P., & Emanueli, C. (2013). MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia. Circulation Research, 112(2), 335-46. https://doi.org/10.1161/CIRCRESAHA.111.300418

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title = "MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia",

abstract = "Circulating proangiogenic cells (PACs) support postischemic neovascularization. Cardiovascular disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that are not fully known. We hypothesize a role for microRNAs (miRs). Circulating miRs are currently investigated as potential diagnostic and prognostic biomarkers.",

keywords = "Animals, Cell Movement, Cell Survival, Cell Transplantation, Cells, Cultured, Diabetes Complications, Diabetes Mellitus, Type 2, HEK293 Cells, Hindlimb, Humans, Ischemia, Mice, Mice, Nude, MicroRNAs, Neovascularization, Pathologic",

author = "Gaia Spinetti and Orazio Fortunato and Andrea Caporali and Saran Shantikumar and Micol Marchetti and Marco Meloni and Betty Descamps and Ilaria Floris and Elena Sangalli and Rosa Vono and Ezio Faglia and Claudia Specchia and Gianfranco Pintus and Paolo Madeddu and Costanza Emanueli",

year = "2013",

month = jan,

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doi = "10.1161/CIRCRESAHA.111.300418",

language = "English",

volume = "112",

pages = "335--46",

journal = "Circulation Research",

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publisher = "Lippincott Williams and Wilkins",

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Spinetti, G, Fortunato, O, Caporali, A, Shantikumar, S, Marchetti, M, Meloni, M, Descamps, B, Floris, I, Sangalli, E, Vono, R, Faglia, E, Specchia, C, Pintus, G, Madeddu, P & Emanueli, C 2013, 'MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia', Circulation Research, vol. 112, no. 2, pp. 335-46. https://doi.org/10.1161/CIRCRESAHA.111.300418

MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia. / Spinetti, Gaia; Fortunato, Orazio; Caporali, Andrea et al.
In: Circulation Research, Vol. 112, No. 2, 18.01.2013, p. 335-46.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia

AU - Spinetti, Gaia

AU - Fortunato, Orazio

AU - Caporali, Andrea

AU - Shantikumar, Saran

AU - Marchetti, Micol

AU - Meloni, Marco

AU - Descamps, Betty

AU - Floris, Ilaria

AU - Sangalli, Elena

AU - Vono, Rosa

AU - Faglia, Ezio

AU - Specchia, Claudia

AU - Pintus, Gianfranco

AU - Madeddu, Paolo

AU - Emanueli, Costanza

PY - 2013/1/18

Y1 - 2013/1/18

N2 - Circulating proangiogenic cells (PACs) support postischemic neovascularization. Cardiovascular disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that are not fully known. We hypothesize a role for microRNAs (miRs). Circulating miRs are currently investigated as potential diagnostic and prognostic biomarkers.

AB - Circulating proangiogenic cells (PACs) support postischemic neovascularization. Cardiovascular disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that are not fully known. We hypothesize a role for microRNAs (miRs). Circulating miRs are currently investigated as potential diagnostic and prognostic biomarkers.

KW - Animals

KW - Cell Movement

KW - Cell Survival

KW - Cell Transplantation

KW - Cells, Cultured

KW - Diabetes Complications

KW - Diabetes Mellitus, Type 2

KW - HEK293 Cells

KW - Hindlimb

KW - Humans

KW - Ischemia

KW - Mice

KW - Mice, Nude

KW - MicroRNAs

KW - Neovascularization, Pathologic

U2 - 10.1161/CIRCRESAHA.111.300418

DO - 10.1161/CIRCRESAHA.111.300418

M3 - Article

C2 - 23233752

SN - 0009-7330

VL - 112

SP - 335

EP - 346

JO - Circulation Research

JF - Circulation Research

IS - 2

ER -

MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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Inter-cellular trafficking and regulation of microRNA-503 expression in diabetes induced microvascular complications

Cite this