MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia

Gaia Spinetti, Orazio Fortunato, Andrea Caporali, Saran Shantikumar, Micol Marchetti, Marco Meloni, Betty Descamps, Ilaria Floris, Elena Sangalli, Rosa Vono, Ezio Faglia, Claudia Specchia, Gianfranco Pintus, Paolo Madeddu, Costanza Emanueli

Research output: Contribution to journalArticlepeer-review

Abstract

Circulating proangiogenic cells (PACs) support postischemic neovascularization. Cardiovascular disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that are not fully known. We hypothesize a role for microRNAs (miRs). Circulating miRs are currently investigated as potential diagnostic and prognostic biomarkers.
Original languageEnglish
Pages (from-to)335-46
Number of pages12
JournalCirculation Research
Volume112
Issue number2
DOIs
Publication statusPublished - 18 Jan 2013

Keywords

  • Animals
  • Cell Movement
  • Cell Survival
  • Cell Transplantation
  • Cells, Cultured
  • Diabetes Complications
  • Diabetes Mellitus, Type 2
  • HEK293 Cells
  • Hindlimb
  • Humans
  • Ischemia
  • Mice
  • Mice, Nude
  • MicroRNAs
  • Neovascularization, Pathologic

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