MicroRNAs in Vascular Remodeling and Repair

Lynsey Howard*, Andrea Caporali, Saran Shantikumar, Costanza Emanueli

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract / Description of output

At the heart of vascular remodeling is a complex network of temporal gene expression coordinated by microRNAs, or miRNAs. Cardiovascular regeneration the generation of new functional cardiomyocytes and therapeutic angiogenesis remains a key goal in cell therapy for vascular and cardiovascular diseases. Cell differentiation elicits a complex concerto of precise miRNA expression for controlling cell fate decisions, function, and engraftment into the host. Limited improvements in animal models of ischemic disease using progenitor cell types have been shown in diseases such as chronic angina, acute MI, and heart failure. These therapies are by no means optimal. Before they can progress to the clinic, more understanding of the transcriptional control of lineage commitment is warranted. This chapter describes the role of microRNAs in vascular remodeling and in cell therapy strategies for treating ischemic diseases.

Original languageEnglish
Title of host publicationMicroRNA in Regenerative Medicine
PublisherElsevier Inc.
Number of pages29
ISBN (Electronic)9780124058583
ISBN (Print)9780124055445
Publication statusPublished - 1 Jan 2015

Keywords / Materials (for Non-textual outputs)

  • Cell-based therapy
  • MicroRNAs
  • MiRNAs
  • Regenerative therapies
  • Stem cells
  • Vascular disease


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