MicroRNAs: New players in IBD

R. Kalla, N. T. Ventham, N. A. Kennedy, J. F. Quintana, E. R. Nimmo, A. H. Buck, J. Satsangi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.

Original languageEnglish
Pages (from-to)504-517
Number of pages14
JournalGut
Volume64
Issue number3
DOIs
Publication statusPublished - 1 Mar 2015

Fingerprint Dive into the research topics of 'MicroRNAs: New players in IBD'. Together they form a unique fingerprint.

Cite this