MicroRNAs: New players in IBD

R. Kalla; N. T. Ventham; N. A. Kennedy; J. F. Quintana; E. R. Nimmo; A. H. Buck; J. Satsangi

doi:10.1136/gutjnl-2014-307891

MicroRNAs: New players in IBD

R. Kalla, N. T. Ventham, N. A. Kennedy, J. F. Quintana, E. R. Nimmo, A. H. Buck, J. Satsangi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.

Original language	English
Pages (from-to)	504-517
Number of pages	14
Journal	Gut
Volume	64
Issue number	3
DOIs	https://doi.org/10.1136/gutjnl-2014-307891
Publication status	Published - 1 Mar 2015

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10.1136/gutjnl-2014-307891

MicroRNAs: New players in IBD
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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title = "MicroRNAs: New players in IBD",

abstract = "MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.",

author = "R. Kalla and Ventham, {N. T.} and Kennedy, {N. A.} and Quintana, {J. F.} and Nimmo, {E. R.} and Buck, {A. H.} and J. Satsangi",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",

year = "2015",

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doi = "10.1136/gutjnl-2014-307891",

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AU - Kalla, R.

AU - Ventham, N. T.

AU - Kennedy, N. A.

AU - Quintana, J. F.

AU - Nimmo, E. R.

AU - Buck, A. H.

AU - Satsangi, J.

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.

AB - MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.

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MicroRNAs: New players in IBD

Abstract / Description of output

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An investigation into the epigenetic alterations in the T Helper 14 pathway in the pathogenensis of Crohns disease

Correction: MicroRNAs: new players in IBD

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MicroRNAs: New players in IBD

Abstract / Description of output

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Other files and links

Fingerprint

Projects

An investigation into the epigenetic alterations in the T Helper 14 pathway in the pathogenensis of Crohns disease

Research output

Correction: MicroRNAs: new players in IBD

Cite this