Microtubule nucleation at non-spindle pole body microtubule-organizing centers requires fission yeast centrosomin-related protein mod20p

Kenneth E Sawin, Paula C C Lourenco, Hilary A Snaith

Research output: Contribution to journalArticlepeer-review

Abstract

Many types of differentiated eukaryotic cells display microtubule distributions consistent with nucleation from noncentrosomal intracellular microtubule organizing centers (MTOCs), although such structures remain poorly characterized. In fission yeast, two types of MTOCs exist in addition to the spindle pole body, the yeast centrosome equivalent. These are the equatorial MTOC, which nucleates microtubules from the cell division site at the end of mitosis, and interphase MTOCs, which nucleate microtubules from multiple sites near the cell nucleus during interphase.
Original languageEnglish
Pages (from-to)763-75
Number of pages13
JournalCurrent biology : CB
Volume14
Issue number9
DOIs
Publication statusPublished - 2004

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