Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides - a gentle heat goes a long way

M A  Fara; J J  Diaz-Mochon; M  Bradley

doi:10.1016/j.tetlet.2005.11.127

Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides - a gentle heat goes a long way

M A Fara, J J Diaz-Mochon, M Bradley

Research output: Contribution to journal › Article › peer-review

Abstract

Mild thermal effects (Arrhenius based) achieved with microwave heating proved to be highly successful in enabling rapid and efficient secondary amine couplings and the labelling of peptides with a variety of fluorophores and quenchers in high yields and purities with just traditional, yet robust, HOBt/DIC chemistry. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	1011-1014
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	6
DOIs	https://doi.org/10.1016/j.tetlet.2005.11.127
Publication status	Published - 6 Feb 2006

Keywords / Materials (for Non-textual outputs)

IRRADIATION
FMOC
DDE

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10.1016/j.tetlet.2005.11.127

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title = "Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides - a gentle heat goes a long way",

abstract = "Mild thermal effects (Arrhenius based) achieved with microwave heating proved to be highly successful in enabling rapid and efficient secondary amine couplings and the labelling of peptides with a variety of fluorophores and quenchers in high yields and purities with just traditional, yet robust, HOBt/DIC chemistry. (c) 2005 Elsevier Ltd. All rights reserved.",

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AU - Fara, M A

AU - Diaz-Mochon, J J

AU - Bradley, M

PY - 2006/2/6

Y1 - 2006/2/6

N2 - Mild thermal effects (Arrhenius based) achieved with microwave heating proved to be highly successful in enabling rapid and efficient secondary amine couplings and the labelling of peptides with a variety of fluorophores and quenchers in high yields and purities with just traditional, yet robust, HOBt/DIC chemistry. (c) 2005 Elsevier Ltd. All rights reserved.

AB - Mild thermal effects (Arrhenius based) achieved with microwave heating proved to be highly successful in enabling rapid and efficient secondary amine couplings and the labelling of peptides with a variety of fluorophores and quenchers in high yields and purities with just traditional, yet robust, HOBt/DIC chemistry. (c) 2005 Elsevier Ltd. All rights reserved.

KW - IRRADIATION

KW - FMOC

KW - DDE

U2 - 10.1016/j.tetlet.2005.11.127

DO - 10.1016/j.tetlet.2005.11.127

M3 - Article

SN - 0040-4039

VL - 47

SP - 1011

EP - 1014

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 6

ER -

Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides - a gentle heat goes a long way

Abstract

Keywords / Materials (for Non-textual outputs)

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