Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides - a gentle heat goes a long way

M A  Fara; J J  Diaz-Mochon; M  Bradley

doi:10.1016/j.tetlet.2005.11.127

Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides - a gentle heat goes a long way

M A Fara, J J Diaz-Mochon, M Bradley

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Mild thermal effects (Arrhenius based) achieved with microwave heating proved to be highly successful in enabling rapid and efficient secondary amine couplings and the labelling of peptides with a variety of fluorophores and quenchers in high yields and purities with just traditional, yet robust, HOBt/DIC chemistry. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	1011-1014
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	6
DOIs	https://doi.org/10.1016/j.tetlet.2005.11.127
Publication status	Published - 6 Feb 2006

Keywords / Materials (for Non-textual outputs)

IRRADIATION
FMOC
DDE

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10.1016/j.tetlet.2005.11.127

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title = "Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides - a gentle heat goes a long way",

abstract = "Mild thermal effects (Arrhenius based) achieved with microwave heating proved to be highly successful in enabling rapid and efficient secondary amine couplings and the labelling of peptides with a variety of fluorophores and quenchers in high yields and purities with just traditional, yet robust, HOBt/DIC chemistry. (c) 2005 Elsevier Ltd. All rights reserved.",

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year = "2006",

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AU - Fara, M A

AU - Diaz-Mochon, J J

AU - Bradley, M

PY - 2006/2/6

Y1 - 2006/2/6

N2 - Mild thermal effects (Arrhenius based) achieved with microwave heating proved to be highly successful in enabling rapid and efficient secondary amine couplings and the labelling of peptides with a variety of fluorophores and quenchers in high yields and purities with just traditional, yet robust, HOBt/DIC chemistry. (c) 2005 Elsevier Ltd. All rights reserved.

AB - Mild thermal effects (Arrhenius based) achieved with microwave heating proved to be highly successful in enabling rapid and efficient secondary amine couplings and the labelling of peptides with a variety of fluorophores and quenchers in high yields and purities with just traditional, yet robust, HOBt/DIC chemistry. (c) 2005 Elsevier Ltd. All rights reserved.

KW - IRRADIATION

KW - FMOC

KW - DDE

U2 - 10.1016/j.tetlet.2005.11.127

DO - 10.1016/j.tetlet.2005.11.127

M3 - Article

SN - 0040-4039

VL - 47

SP - 1011

EP - 1014

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 6

ER -

Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides - a gentle heat goes a long way

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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