Mid-luteal endometrial intracrinology following controlled ovarian hyperstimulation involving use of a gonadotrophin releasing hormone antagonist

Susheel Vani; Sarah E McDonald; Alistair R W Williams; J Ian Mason; K Joo Thong; Hilary O D Critchley

doi:10.1093/humrep/dem269

Mid-luteal endometrial intracrinology following controlled ovarian hyperstimulation involving use of a gonadotrophin releasing hormone antagonist

Susheel Vani, Sarah E McDonald, Alistair R W Williams, J Ian Mason, K Joo Thong, Hilary O D Critchley

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

There are concerns of reduced pregnancy rates with the use of gonadotrophin-releasing hormone antagonists (GnRH antagonists) in IVF/ICSI cycles. Sex steroids and their metabolizing enzymes in the endometrium may play a vital role in embryo implantation. This study has evaluated the levels and localization of sex-steroid receptors and metabolizing enzymes, 3beta-hydroxysteroid dehydrogenases (3betaHSD) and selected 17beta-HSD (17betaHSD), in mid-luteal endometrium of women treated with GnRH antagonist (Cetrorelix) and recombinant FSH (rFSH; Gonal-F) with luteal phase progesterone supplementation.

Original language	English
Pages (from-to)	2981-91
Number of pages	11
Journal	Human Reproduction
Volume	22
Issue number	11
DOIs	https://doi.org/10.1093/humrep/dem269
Publication status	Published - 2007

Access to Document

10.1093/humrep/dem269

Local Cortisol (CORT) Regulation in Ovarian and Uterine Disorders
Critchley, H.
MRC
1/10/05 → 31/10/20
Project: Research
Injury and repair in the female reproductive tract
Critchley, H., Hillier, S. & Mason, I.
MRC
1/10/00 → 30/09/05
Project: Research

Cite this

@article{baf53d579c4740218e7ba74a1de3f270,

title = "Mid-luteal endometrial intracrinology following controlled ovarian hyperstimulation involving use of a gonadotrophin releasing hormone antagonist",

abstract = "There are concerns of reduced pregnancy rates with the use of gonadotrophin-releasing hormone antagonists (GnRH antagonists) in IVF/ICSI cycles. Sex steroids and their metabolizing enzymes in the endometrium may play a vital role in embryo implantation. This study has evaluated the levels and localization of sex-steroid receptors and metabolizing enzymes, 3beta-hydroxysteroid dehydrogenases (3betaHSD) and selected 17beta-HSD (17betaHSD), in mid-luteal endometrium of women treated with GnRH antagonist (Cetrorelix) and recombinant FSH (rFSH; Gonal-F) with luteal phase progesterone supplementation.",

author = "Susheel Vani and McDonald, {Sarah E} and Williams, {Alistair R W} and Mason, {J Ian} and Thong, {K Joo} and Critchley, {Hilary O D}",

year = "2007",

doi = "10.1093/humrep/dem269",

language = "English",

volume = "22",

pages = "2981--91",

journal = "Human Reproduction",

issn = "0268-1161",

publisher = "Oxford University Press",

number = "11",

}

TY - JOUR

T1 - Mid-luteal endometrial intracrinology following controlled ovarian hyperstimulation involving use of a gonadotrophin releasing hormone antagonist

AU - Vani, Susheel

AU - McDonald, Sarah E

AU - Williams, Alistair R W

AU - Mason, J Ian

AU - Thong, K Joo

AU - Critchley, Hilary O D

PY - 2007

Y1 - 2007

N2 - There are concerns of reduced pregnancy rates with the use of gonadotrophin-releasing hormone antagonists (GnRH antagonists) in IVF/ICSI cycles. Sex steroids and their metabolizing enzymes in the endometrium may play a vital role in embryo implantation. This study has evaluated the levels and localization of sex-steroid receptors and metabolizing enzymes, 3beta-hydroxysteroid dehydrogenases (3betaHSD) and selected 17beta-HSD (17betaHSD), in mid-luteal endometrium of women treated with GnRH antagonist (Cetrorelix) and recombinant FSH (rFSH; Gonal-F) with luteal phase progesterone supplementation.

AB - There are concerns of reduced pregnancy rates with the use of gonadotrophin-releasing hormone antagonists (GnRH antagonists) in IVF/ICSI cycles. Sex steroids and their metabolizing enzymes in the endometrium may play a vital role in embryo implantation. This study has evaluated the levels and localization of sex-steroid receptors and metabolizing enzymes, 3beta-hydroxysteroid dehydrogenases (3betaHSD) and selected 17beta-HSD (17betaHSD), in mid-luteal endometrium of women treated with GnRH antagonist (Cetrorelix) and recombinant FSH (rFSH; Gonal-F) with luteal phase progesterone supplementation.

U2 - 10.1093/humrep/dem269

DO - 10.1093/humrep/dem269

M3 - Article

C2 - 17848403

SN - 0268-1161

VL - 22

SP - 2981

EP - 2991

JO - Human Reproduction

JF - Human Reproduction

IS - 11

ER -

Mid-luteal endometrial intracrinology following controlled ovarian hyperstimulation involving use of a gonadotrophin releasing hormone antagonist

Abstract / Description of output

Access to Document

Fingerprint

Projects

Local Cortisol (CORT) Regulation in Ovarian and Uterine Disorders

Injury and repair in the female reproductive tract

Cite this