Midwall Fibrosis Is an Independent Predictor of Mortality in Patients With Aortic Stenosis

Marc R Dweck, Sanjiv Joshi, Timothy Murigu, Francisco Alpendurada, Andrew Jabbour, Giovanni Melina, Winston Banya, Ankur Gulati, Isabelle Roussin, Sadaf Raza, Nishant A Prasad, Rick Wage, Cesare Quarto, Emiliano Angeloni, Simone Refice, Mary Sheppard, Stuart A Cook, Philip J Kilner, Dudley J Pennell, David E NewbyRaad H Mohiaddin, John Pepper, Sanjay K Prasad

Research output: Contribution to journalArticlepeer-review


The goal of this study was to assess the prognostic significance of midwall and infarct patterns of late gadolinium enhancement (LGE) in aortic stenosis.

Myocardial fibrosis occurs in aortic stenosis as part of the hypertrophic response. It can be detected by LGE, which is associated with an adverse prognosis in a range of other cardiac conditions.

Between January 2003 and October 2008, consecutive patients with moderate or severe aortic stenosis undergoing cardiovascular magnetic resonance with administration of gadolinium contrast were enrolled into a registry. Patients were categorized into absent, midwall, or infarct patterns of LGE by blinded independent observers. Patient follow-up was completed using patient questionnaires, source record data, and the National Strategic Tracing Service.

A total of 143 patients (age 68 ± 14 years; 97 male) were followed up for 2.0 ± 1.4 years. Seventy-two underwent aortic valve replacement, and 27 died (24 cardiac, 3 sudden cardiac deaths). Compared with those with no LGE (n = 49), univariate analysis revealed that patients with midwall fibrosis (n = 54) had an 8-fold increase in all-cause mortality despite similar aortic stenosis severity and coronary artery disease burden. Patients with an infarct pattern (n = 40) had a 6-fold increase. Midwall fibrosis (hazard ratio: 5.35; 95% confidence interval: 1.16 to 24.56; p = 0.03) and ejection fraction (hazard ratio: 0.96; 95% confidence interval: 0.94 to 0.99; p = 0.01) were independent predictors of all-cause mortality by multivariate analysis.

Midwall fibrosis was an independent predictor of mortality in patients with moderate and severe aortic stenosis. It has incremental prognostic value to ejection fraction and may provide a useful method of risk stratification.
Original languageEnglish
Pages (from-to)1271–1279
Number of pages9
JournalJournal of the American College of Cardiology
Issue number12
Publication statusPublished - Sep 2011


  • aortic valve stenosis
  • gadolinium
  • mortality
  • myocardial fibrosis
  • myocardial infarction


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