Mild and Low-Pressure fac-Ir(ppy)3 -Mediated Radical Aminocarbonylation of Unactivated Alkyl Iodides through Visible-Light Photoredox Catalysis

Shiao Y Chow, Marc Y Stevens, Linda Åkerbladh, Sara Bergman, Luke R Odell

Research output: Contribution to journalArticlepeer-review

Abstract

A novel, mild and facile preparation of alkyl amides from unactivated alkyl iodides employing a fac-Ir(ppy)3 -catalyzed radical aminocarbonylation protocol has been developed. Using a two-chambered system, alkyl iodides, fac-Ir(ppy)3 , amines, reductants, and CO gas (released ex situ from Mo(CO)6 ), were combined and subjected to an initial radical reductive dehalogenation generating alkyl radicals, and a subsequent aminocarbonylation with amines affording a wide range of alkyl amides in moderate to excellent yields.

Original languageEnglish
Pages (from-to)9155-61
Number of pages7
JournalChemistry - A European Journal
Volume22
Issue number27
Early online date7 Jun 2016
DOIs
Publication statusPublished - 27 Jun 2016

Fingerprint

Dive into the research topics of 'Mild and Low-Pressure fac-Ir(ppy)3 -Mediated Radical Aminocarbonylation of Unactivated Alkyl Iodides through Visible-Light Photoredox Catalysis'. Together they form a unique fingerprint.

Cite this