Mineralocorticoid receptor expression and increased survival following neuronal injury

Malcolm R. Macleod*, Inga Maj Johansson, Ingegerd Söderström, Maggie Lai, Gunilla Gidö, Tadeusz Wieloch, Jonathan R. Seckl, Tommy Olsson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Glucocorticoids, acting via the mineralocorticoid receptor, are required for granule neuronal survival in the rat dentate gyrus. Whether this mineralocorticoid receptor-mediated neuroprotective effect has more general applicability is unknown. Here we report increased mineralocorticoid receptor expression in rat hippocampal and cortical neurons exposed in vitro to low levels of staurosporine and in rat hippocampal pyramidal neurons exposed in vivo to hypothermic transient global ischaemia. In both the cell culture system and the in vivo system increased mineralocorticoid receptor expression is associated with increased neuronal survival, and this increase is reversed by mineralocorticoid receptor antagonism. Modulation of mineralocorticoid receptor gene expression may therefore be an important target for reduction of brain injury in conditions caused by cerebral ischaemia including brain damage following cardiac arrest and stroke.

Original languageEnglish
Pages (from-to)1549-1555
Number of pages7
JournalEuropean Journal of Neuroscience
Issue number8
Publication statusPublished - Apr 2003

Keywords / Materials (for Non-textual outputs)

  • Hypothermia
  • Ischaemia
  • Neuronal death
  • Rat
  • Staurosporine


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