Mineralocorticoid receptor expression and increased survival following neuronal injury

Malcolm R. Macleod; Inga Maj Johansson; Ingegerd Söderström; Maggie Lai; Gunilla Gidö; Tadeusz Wieloch; Jonathan R. Seckl; Tommy Olsson

doi:10.1046/j.1460-9568.2003.02587.x

Mineralocorticoid receptor expression and increased survival following neuronal injury

Malcolm R. Macleod^*, Inga Maj Johansson, Ingegerd Söderström, Maggie Lai, Gunilla Gidö, Tadeusz Wieloch, Jonathan R. Seckl, Tommy Olsson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Glucocorticoids, acting via the mineralocorticoid receptor, are required for granule neuronal survival in the rat dentate gyrus. Whether this mineralocorticoid receptor-mediated neuroprotective effect has more general applicability is unknown. Here we report increased mineralocorticoid receptor expression in rat hippocampal and cortical neurons exposed in vitro to low levels of staurosporine and in rat hippocampal pyramidal neurons exposed in vivo to hypothermic transient global ischaemia. In both the cell culture system and the in vivo system increased mineralocorticoid receptor expression is associated with increased neuronal survival, and this increase is reversed by mineralocorticoid receptor antagonism. Modulation of mineralocorticoid receptor gene expression may therefore be an important target for reduction of brain injury in conditions caused by cerebral ischaemia including brain damage following cardiac arrest and stroke.

Original language	English
Pages (from-to)	1549-1555
Number of pages	7
Journal	European Journal of Neuroscience
Volume	17
Issue number	8
DOIs	https://doi.org/10.1046/j.1460-9568.2003.02587.x
Publication status	Published - Apr 2003

Keywords / Materials (for Non-textual outputs)

Hypothermia
Ischaemia
Neuronal death
Rat
Staurosporine

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10.1046/j.1460-9568.2003.02587.x

Cite this

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title = "Mineralocorticoid receptor expression and increased survival following neuronal injury",

abstract = "Glucocorticoids, acting via the mineralocorticoid receptor, are required for granule neuronal survival in the rat dentate gyrus. Whether this mineralocorticoid receptor-mediated neuroprotective effect has more general applicability is unknown. Here we report increased mineralocorticoid receptor expression in rat hippocampal and cortical neurons exposed in vitro to low levels of staurosporine and in rat hippocampal pyramidal neurons exposed in vivo to hypothermic transient global ischaemia. In both the cell culture system and the in vivo system increased mineralocorticoid receptor expression is associated with increased neuronal survival, and this increase is reversed by mineralocorticoid receptor antagonism. Modulation of mineralocorticoid receptor gene expression may therefore be an important target for reduction of brain injury in conditions caused by cerebral ischaemia including brain damage following cardiac arrest and stroke.",

keywords = "Hypothermia, Ischaemia, Neuronal death, Rat, Staurosporine",

author = "Macleod, {Malcolm R.} and Johansson, {Inga Maj} and Ingegerd S{\"o}derstr{\"o}m and Maggie Lai and Gunilla Gid{\"o} and Tadeusz Wieloch and Seckl, {Jonathan R.} and Tommy Olsson",

year = "2003",

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doi = "10.1046/j.1460-9568.2003.02587.x",

language = "English",

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pages = "1549--1555",

journal = "European Journal of Neuroscience",

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TY - JOUR

T1 - Mineralocorticoid receptor expression and increased survival following neuronal injury

AU - Macleod, Malcolm R.

AU - Johansson, Inga Maj

AU - Söderström, Ingegerd

AU - Lai, Maggie

AU - Gidö, Gunilla

AU - Wieloch, Tadeusz

AU - Seckl, Jonathan R.

AU - Olsson, Tommy

PY - 2003/4

Y1 - 2003/4

N2 - Glucocorticoids, acting via the mineralocorticoid receptor, are required for granule neuronal survival in the rat dentate gyrus. Whether this mineralocorticoid receptor-mediated neuroprotective effect has more general applicability is unknown. Here we report increased mineralocorticoid receptor expression in rat hippocampal and cortical neurons exposed in vitro to low levels of staurosporine and in rat hippocampal pyramidal neurons exposed in vivo to hypothermic transient global ischaemia. In both the cell culture system and the in vivo system increased mineralocorticoid receptor expression is associated with increased neuronal survival, and this increase is reversed by mineralocorticoid receptor antagonism. Modulation of mineralocorticoid receptor gene expression may therefore be an important target for reduction of brain injury in conditions caused by cerebral ischaemia including brain damage following cardiac arrest and stroke.

AB - Glucocorticoids, acting via the mineralocorticoid receptor, are required for granule neuronal survival in the rat dentate gyrus. Whether this mineralocorticoid receptor-mediated neuroprotective effect has more general applicability is unknown. Here we report increased mineralocorticoid receptor expression in rat hippocampal and cortical neurons exposed in vitro to low levels of staurosporine and in rat hippocampal pyramidal neurons exposed in vivo to hypothermic transient global ischaemia. In both the cell culture system and the in vivo system increased mineralocorticoid receptor expression is associated with increased neuronal survival, and this increase is reversed by mineralocorticoid receptor antagonism. Modulation of mineralocorticoid receptor gene expression may therefore be an important target for reduction of brain injury in conditions caused by cerebral ischaemia including brain damage following cardiac arrest and stroke.

KW - Hypothermia

KW - Ischaemia

KW - Neuronal death

KW - Rat

KW - Staurosporine

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U2 - 10.1046/j.1460-9568.2003.02587.x

DO - 10.1046/j.1460-9568.2003.02587.x

M3 - Article

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AN - SCOPUS:0038356259

SN - 0953-816X

VL - 17

SP - 1549

EP - 1555

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

IS - 8

ER -

Mineralocorticoid receptor expression and increased survival following neuronal injury

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Keywords / Materials (for Non-textual outputs)

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