Minimum information about a bioactive entity (MIABE)

Sandra Orchard, Bissan Al-Lazikani, Steve Bryant, Dominic Clark, Elizabeth Calder, Ian Dix, Ola Engkvist, Mark Forster, Anna Gaulton, Michael Gilson, Robert Glen, Martin Grigorov, Kim Hammond-Kosack, Lee Harland, Andrew Hopkins, Christopher Larminie, Nick Lynch, Romeena K Mann, Peter Murray-Rust, Elena Lo PiparoChristopher Southan, Christoph Steinbeck, David Wishart, Henning Hermjakob, John Overington, Janet Thornton

Research output: Contribution to journalArticlepeer-review

Abstract

Bioactive molecules such as drugs, pesticides and food additives are produced in large numbers by many commercial and academic groups around the world. Enormous quantities of data are generated on the biological properties and quality of these molecules. Access to such data - both on licensed and commercially available compounds, and also on those that fail during development - is crucial for understanding how improved molecules could be developed. For example, computational analysis of aggregated data on molecules that are investigated in drug discovery programmes has led to a greater understanding of the properties of successful drugs. However, the information required to perform these analyses is rarely published, and when it is made available it is often missing crucial data or is in a format that is inappropriate for efficient data-mining. Here, we propose a solution: the definition of reporting guidelines for bioactive entities - the Minimum Information About a Bioactive Entity (MIABE) - which has been developed by representatives of pharmaceutical companies, data resource providers and academic groups.

Original languageEnglish
Pages (from-to)661-9
Number of pages9
JournalNature Reviews Drug Discovery
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Animals
  • Biomarkers
  • Chemical Industry
  • Chemistry, Physical
  • Communication
  • Data Collection
  • Drug Design
  • Drug Industry
  • Guidelines as Topic
  • Humans
  • Information Dissemination
  • Pesticides
  • Pharmaceutical Preparations
  • Pharmacokinetics
  • Terminology as Topic
  • Toxicology

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