miRNAs in development and pathogenesis of the nervous system

Jakub S Nowak, Gracjan Michlewski

Research output: Contribution to journalArticlepeer-review

Abstract

The human nervous system expresses approximately 70% of all miRNAs (microRNAs). Changing levels of certain ubiquitous and brain-specific miRNAs shape the development and function of the nervous system. It is becoming clear that misexpression of some miRNAs can contribute towards neurodevelopmental disorders. In the present article, we review the current knowledge of the role of miRNAs in development and pathogenesis of the nervous system.
Original languageEnglish
Pages (from-to)815-820
Number of pages6
JournalBiochemical Society Transactions
Volume41
Issue number4
DOIs
Publication statusPublished - 18 Jul 2013

Keywords

  • microRNA (miRNA)
  • microRNA biogenesis
  • nervous system
  • neuropathogenesis
  • synaptic plasticity

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