Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

Graham R Campbell, Iryna Ziabreva, Amy K Reeve, Kim J Krishnan, Richard Reynolds, Owen Howell, Hans Lassmann, Doug M Turnbull, Don J Mahad

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely, mitochondria harbor their own mitochondrial DNA (mtDNA), essential for maintaining a healthy central nervous system. We explored mitochondrial respiratory chain activity and mtDNA deletions in single neurons from secondary progressive MS (SPMS) cases.
Original languageEnglish
Pages (from-to)481-92
Number of pages12
JournalAnnals of Neurology
Volume69
Issue number3
DOIs
Publication statusPublished - 2011

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