Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

Graham R Campbell; Iryna Ziabreva; Amy K Reeve; Kim J Krishnan; Richard Reynolds; Owen Howell; Hans Lassmann; Doug M Turnbull; Don J Mahad

doi:10.1002/ana.22109

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

Graham R Campbell, Iryna Ziabreva, Amy K Reeve, Kim J Krishnan, Richard Reynolds, Owen Howell, Hans Lassmann, Doug M Turnbull, Don J Mahad

Research output: Contribution to journal › Article › peer-review

Abstract

Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely, mitochondria harbor their own mitochondrial DNA (mtDNA), essential for maintaining a healthy central nervous system. We explored mitochondrial respiratory chain activity and mtDNA deletions in single neurons from secondary progressive MS (SPMS) cases.

Original language	English
Pages (from-to)	481-92
Number of pages	12
Journal	Annals of Neurology
Volume	69
Issue number	3
DOIs	https://doi.org/10.1002/ana.22109
Publication status	Published - 2011

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10.1002/ana.22109

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis
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title = "Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis",

abstract = "Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely, mitochondria harbor their own mitochondrial DNA (mtDNA), essential for maintaining a healthy central nervous system. We explored mitochondrial respiratory chain activity and mtDNA deletions in single neurons from secondary progressive MS (SPMS) cases.",

author = "Campbell, \{Graham R\} and Iryna Ziabreva and Reeve, \{Amy K\} and Krishnan, \{Kim J\} and Richard Reynolds and Owen Howell and Hans Lassmann and Turnbull, \{Doug M\} and Mahad, \{Don J\}",

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AU - Campbell, Graham R

AU - Ziabreva, Iryna

AU - Reeve, Amy K

AU - Krishnan, Kim J

AU - Reynolds, Richard

AU - Howell, Owen

AU - Lassmann, Hans

AU - Turnbull, Doug M

AU - Mahad, Don J

PY - 2011

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AB - Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely, mitochondria harbor their own mitochondrial DNA (mtDNA), essential for maintaining a healthy central nervous system. We explored mitochondrial respiratory chain activity and mtDNA deletions in single neurons from secondary progressive MS (SPMS) cases.

U2 - 10.1002/ana.22109

DO - 10.1002/ana.22109

M3 - Article

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SN - 1531-8249

VL - 69

SP - 481

EP - 492

JO - Annals of Neurology

JF - Annals of Neurology

IS - 3

ER -

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

Abstract

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