Mitochondrial respiratory complex I proteostasis: The role of a subunit turnover rate

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Abstract / Description of output

The mitochondrial respiratory Complex I (CI) catalyzes the first step in the electron transport chain and contributes to generating the proton gradient across membranes required for ATP synthesis (Maldonado et al. 2020). Intrinsic to its enzymatic activity and subcellular environment, CI is prone to oxidative damage and displays a relatively high turnover rate. Despite its importance in bioenergetics, the control of CI stability and activity is not fully understood. In this issue of The Plant Cell, Abi S. Ghifari and colleagues (Ghifari et al. 2023) investigate the mechanisms controlling CI proteostasis and show that a mitochondrial chaperone facilitates complex disassembly and turnover. This work sheds light on long-standing questions about the mechanisms controlling CI homeostasis and demonstrates how protein complex activity is tuned by the turnover of individual subunits.
Original languageEnglish
Article numberkoad149
Pages (from-to)2720-2721
Number of pages2
JournalThe Plant cell
Volume35
Issue number8
Early online date23 May 2023
DOIs
Publication statusPublished - 8 Jun 2023

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