Mitochondrial tumour suppressors: a genetic and biochemical update

Eyal Gottlieb, Ian P. M. Tomlinson

Research output: Contribution to journalArticlepeer-review

Abstract

Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (SDHB, SDHC and fumarate hydratase) have been implicated in tumour susceptibility. Mutations in these proteins are principally involved in familial predisposition to benign tumours, but the spectrum of inherited lesions is increasingly recognized to include malignant tumours, such as malignant phaeochromocytomas and renal cell carcinomas. Here we review recent advances in the field of mitochondrial tumour suppressors, the biochemical pathway that links mitochondrial dysfunction with tumorigenesis, and potential therapeutic approaches to these malignancies.
Original languageEnglish
Pages (from-to)857-866
JournalNature Reviews Cancer
Volume5
Issue number11
DOIs
Publication statusPublished - 1 Nov 2005

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