Mixed-mode oscillations in a three time-scale model for the dopaminergic neuron

Martin Krupa, Nikola Popovic, Nancy Kopell, Horacio G. Rotstein

Research output: Contribution to journalArticlepeer-review

Abstract

Mixed- mode dynamics is a complex type of dynamical behavior that has been observed both numerically and experimentally in numerous prototypical systems in the natural sciences. The compartmental Wilson- Callaway model for the dopaminergic neuron is an example of a system that exhibits a wide variety of mixed- mode patterns upon variation of a control parameter. One characteristic feature of this system is the presence of multiple time scales. In this article, we study the Wilson- Callaway model from a geometric point of view. We show that the observed mixed- mode dynamics is caused by a slowly varying canard structure. By appropriately transforming the model equations, we reduce them to an underlying three- dimensional canonical form that can be analyzed via a slight adaptation of the approach developed by M. Krupa, N. Popovic, and N. Kopell ( unpublished ). (C) 2008 American Institute of Physics.

Original languageEnglish
Article number015106
Pages (from-to)-
Number of pages19
JournalChaos
Volume18
Issue number1
DOIs
Publication statusPublished - Mar 2008

Keywords

  • TRANSIENT DYNAMICS
  • CANARDS
  • GEOMETRY
  • R-3

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