@article{154e59cec4154e43beee2dd5be4b59ff,
title = "Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination",
abstract = "The gut microbiota in early life, when critical immune maturation takes place, may influence the immunogenicity of childhood vaccinations. We assess the association between mode of delivery, gut microbiota development in the first year of life, and mucosal antigen-specific antibody responses against pneumococcal vaccination in 101 infants at age 12 months and against meningococcal vaccination in 66 infants at age 18 months. Birth by vaginal delivery is associated with higher antibody responses against both vaccines. Relative abundances of vaginal birth-associated Bifidobacterium and Escherichia coli in the first weeks of life are positively associated with anti-pneumococcal antibody responses, and relative abundance of E. coli in the same period is also positively associated with anti-meningococcal antibody responses. In this study, we show that mode of delivery-induced microbiota profiles of the gut are associated with subsequent antibody responses to routine childhood vaccines.",
author = "{de Koff}, {Emma M} and {van Baarle}, Debbie and {van Houten}, Marlies and Marta Reyman and Berbers, {Guy A M} and {van den Ham}, Femke and Chu, {Mei Ling} and Sanders, {Elisabeth A M} and Debby Bogaert and Susana Fuentes",
note = "Funding Information: This work was funded by the Netherlands Organization for Scientific Research (NWO-VIDI; grant number 91715359, recipient: D.B.), Chief Scientist Office/NHS Research Scotland Scottish Senior Clinical Fellowship award (SCAF/16/03, recipient: D.B.), Spaarne Gasthuis, University Medical Center Utrecht, Dutch Ministry of Health, Welfare and Sport and the Strategic Program of the National Institute for Public Health and the Environment (SPR; grant number S/112009, recipient: S.F.). The authors are indebted to all the participating children and their families. We thank all the members of the research team of the Spaarne Gasthuis Academy, the laboratory staff, and the Streeklaboratorium Haarlem. We are grateful to Belinda van {\textquoteleft}t Land from Nutricia for providing some of the reagents. Funding Information: This work was funded by the Netherlands Organization for Scientific Research (NWO-VIDI; grant number 91715359, recipient: D.B.), Chief Scientist Office/NHS Research Scotland Scottish Senior Clinical Fellowship award (SCAF/16/03, recipient: D.B.), Spaarne Gasthuis, University Medical Center Utrecht, Dutch Ministry of Health, Welfare and Sport and the Strategic Program of the National Institute for Public Health and the Environment (SPR; grant number S/112009, recipient: S.F.). The authors are indebted to all the participating children and their families. We thank all the members of the research team of the Spaarne Gasthuis Academy, the laboratory staff, and the Streeklaboratorium Haarlem. We are grateful to Belinda van {\textquoteleft}t Land from Nutricia for providing some of the reagents. Funding Information: D.B. received funding from OM pharma and Sanofi. All authors declare no other competing interests. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = nov,
day = "15",
doi = "10.1038/s41467-022-34155-2",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}