Model for quorum-sensing mediated stochastic biofilm nucleation

Patrick Sinclair, Chris A. Brackley, Martin Carballo-Pacheco, R. J. Allen

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Surface-attached bacterial biofilms cause disease and industrial biofouling, as well as being widespread in the natural environment. Density-dependent quorum sensing is one of the mechanisms implicated in biofilm initiation. Here we present and analyse a model for quorum-sensing triggered biofilm initiation. In our model, individual, planktonic bacteria adhere to a surface, proliferate and undergo a collective transition to a biofilm phenotype. This model predicts a stochastic transition between a loosely attached, finite, layer of bacteria near the surface, and a growing biofilm. The transition is governed by two key parameters: the collective transition density relative to the carrying capacity, and the immigration rate relative to the detachment rate. Biofilm initiation is complex, but our model suggests that stochastic nucleation phenomena may be relevant.
Original languageEnglish
Article number198102
Pages (from-to)1-6
Number of pages6
JournalPhysical Review Letters
Volume129
Issue number19
Early online date2 Nov 2022
DOIs
Publication statusPublished - 4 Nov 2022

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