Model Reduction of Genetic-Metabolic Networks via Time Scale Separation

Juan Kuntz, Diego Oyarzún, Guy-Bart Stan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Model reduction techniques often prove indispensable in the analysis of physical and biological phenomena. A succesful reduction technique can substantially simplify a model while retaining all of its pertinent features. In metabolic networks, metabolites evolve on much shorter time scales than the catalytic enzymes. In this chapter, we exploit this discrepancy to justify the reduction via time scale separation of a class of models of metabolic networks under genetic regulation . We formalise the concept of a metabolic network and employ Tikhonov's Theorem for singularly perturbed systems. We demonstrate the applicability of our result by using it to address a problem in metabolic engineering: the genetic control of branched metabolic pathways. We conclude by providing guidelines on how to generalise our result to larger classes of networks.
Original languageEnglish
Title of host publicationA Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations
EditorsVishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman
Place of PublicationDordrecht
PublisherSpringer Netherlands
Pages181-210
Number of pages30
ISBN (Print)978-94-017-9041-3
DOIs
Publication statusPublished - 2014

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