Model Selection Approach Suggests Causal Association between 25-Hydroxyvitamin D and Colorectal Cancer

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Abstract

Vitamin D deficiency has been associated with increased risk of colorectal cancer (CRC), but causal relationship has not yet been confirmed. We investigate the direction of causation between vitamin D and CRC by extending the conventional approaches to allow pleiotropic relationships and by explicitly modelling unmeasured confounders.
Original languageEnglish
Article numbere63475
Number of pages11
JournalPLoS ONE
Volume8
Issue number5
DOIs
Publication statusPublished - 24 May 2013

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