Modeling of oscillations of two activities of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

BN Goldshtein, II Goryanin

Research output: Contribution to journalArticlepeer-review

Abstract

Experimentally observed oscillations in substrate levels of a bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from rat liver were simulated with a mathematical model proposed by the authors earlier and predicting this phenomenon. A nice fit between theory and experiment was obtained for the period, amplitude, and fading of oscillations. Analysis of the model provided a better understanding of the role of separate enzymatic stages in generating the oscillations and regulating the metabolic fluxes in liver. Explanation was given to the critical switchover of glycolytic fluxes upon changes of the influx to the modeled system.
Original languageEnglish
Pages (from-to)554-558
Number of pages5
JournalMolecular Biology
Volume30
Issue number4
Publication statusPublished - 1996

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