Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating brain energetics

Tracy Moroz, Tharindi Hapuarachchi, Alan Bainbridge, David Price, Ernest Cady, Ether Baer, Kevin Broad, Mojgan Ezzati, David Thomas, Xavier Golay, Nicola J Robertson, Chris E Cooper, Ilias Tachtsidis

Research output: Contribution to journalArticlepeer-review

Abstract

We have developed a computational model to simulate hypoxia-ischaemia (HI) in the neonatal piglet brain. It has been extended from a previous model by adding the simulation of carotid artery occlusion and including pH changes in the cytoplasm. Here, simulations from the model are compared with near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (MRS) measurements from two piglets during HI and short-term recovery. One of these piglets showed incomplete recovery after HI, and this is modelled by considering some of the cells to be dead. This is consistent with the results from MRS and the redox state of cytochrome-c-oxidase as measured by NIRS. However, the simulations do not match the NIRS haemoglobin measurements. The model therefore predicts that further physiological changes must also be taking place if the hypothesis of dead cells is correct.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalAdvances in Experimental Medicine and Biology
Volume789
DOIs
Publication statusPublished - 2013

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Animals, Newborn/metabolism
  • Brain/blood supply
  • Carotid Arteries/metabolism
  • Cerebrovascular Circulation
  • Disease Models, Animal
  • Electron Transport Complex IV/metabolism
  • Energy Metabolism
  • Hemoglobins/metabolism
  • Hydrogen-Ion Concentration
  • Hypoxia-Ischemia, Brain/blood
  • Magnetic Resonance Spectroscopy/methods
  • Oxidation-Reduction
  • Oxygen Consumption/physiology
  • Spectroscopy, Near-Infrared/methods
  • Swine

Fingerprint

Dive into the research topics of 'Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating brain energetics'. Together they form a unique fingerprint.

Cite this