Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating pH changes

Tharindi Hapuarachchi, Tracy Moroz, Alan Bainbridge, David Price, Ernest Cady, Esther Baer, Kevin Broad, Mojgan Ezzati, David Thomas, Xavier Golay, Nicola J Robertson, Ilias Tachtsidis

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.

Original languageEnglish
Pages (from-to)331-337
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Volume789
DOIs
Publication statusPublished - 2013

Keywords

  • Animals
  • Animals, Newborn
  • Brain/blood supply
  • Cerebrovascular Circulation
  • Disease Models, Animal
  • Hydrogen-Ion Concentration
  • Hypoxia-Ischemia, Brain/metabolism
  • Magnetic Resonance Spectroscopy/methods
  • Models, Cardiovascular
  • Oxygen/metabolism
  • Oxygen Consumption/physiology
  • Spectroscopy, Near-Infrared/methods
  • Swine

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