Modelling cystic fibrosis in the mouse

P Dickinson, J R Dorin, D J Porteous

Research output: Contribution to journalArticlepeer-review


Animal models of human diseases are of vital importance, both for understanding basic disease mechanisms, and for developing potential treatments. Recent advances in molecular biology have helped identify the lesions underlying many genetic diseases. In conjunction with the development of techniques for manipulating the mouse embryo the possibility of mimicking these diseases in vivo has been raised. The example of cystic fibrosis illustrates this potential very well, demonstrating the usefulness of mouse models for gaining an improved understanding of the disease in humans and for the testing of new treatments.
Original languageEnglish
Pages (from-to)140-8
Number of pages9
JournalMolecular medicine today
Issue number3
Publication statusPublished - 1995


  • Animals
  • Cystic Fibrosis
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Disease Models, Animal
  • Electrophysiology
  • Humans
  • Lung Diseases
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Mutation
  • Phenotype


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