Modelling polylactide/water/dioxane systems for TIPS scaffold fabrication

G. Cocchi, M.G.D. Angelis, G. Sadowski, F. Doghieri

Research output: Contribution to journalArticlepeer-review

Abstract

The representation of liquid-liquid equilibria (LLE) in ternary systems composed by water, 1,4-dioxane and different grades of poly(lactic acid) (PDLLA and PLLA), has been addressed through the PC-SAFT equation of state (EoS), in which the scheme of induced association is used to represent the interaction between solvent (dioxane) and non-solvent (water). The model parameters devoted to the description of pure component properties, as well as those pertinent to the representation of thermodynamic behaviour of solvent/non-solvent mixtures, were tuned on the basis of specific pressure-volume-temperature (PVT) data for the corresponding systems. Only the binary parameters for polymer-solvent and polymer/non-solvent pairs were adjusted to obtain a useful representation of experimental LLE data for the ternary systems. A suitable description of the thermodynamic properties of ternary mixtures was obtained using temperature-independent binary interaction parameters in the range 25-80. °C, and the consistency of the approach in the entire composition range was verified against experimental solubility data specifically measured for the polymer/non-solvent pair. The model shows good ability in the description of the thermodynamic properties of the system and it represents a reliable tool for the prediction of LLE also at conditions different from those considered for its set-up. This approach thus represents a useful designing tool for processes, such as thermally induced phase separation (TIPS), used in the preparation of microporous polymeric scaffolds. © 2014 Elsevier B.V.
Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalFluid phase equilibria
Volume374
DOIs
Publication statusPublished - 2014

Keywords

  • Association reactions
  • Equations of state
  • Ethers
  • Mixtures
  • Phase equilibria
  • Phase separation
  • Polymers
  • Polyols
  • Scaffolds
  • Solvents
  • Ternary systems
  • Thermodynamic properties
  • Tools
  • Binary interaction parameter
  • Experimental solubility datum
  • Liquid liquid equilibrium
  • Liquid-liquid-equilibria
  • PC-SAFT
  • Pressure-volume-temperatures
  • Thermally induced phase separation
  • TIPS
  • Scaffolds (biology)

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