Modelling steroidogenesis: a framework model to support hypothesis generation and testing across endocrine studies

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  How does pituitary androgen signalling support lifelong health and wellbeing? An integrated transgenic and systems biology approach

  Smith, L. (Principal Investigator), Freeman, T. (Co-investigator), Le Tissier, P. (Co-investigator), O'Hara, L. (Co-investigator) & O'Hara, L. (Co-Investigator (External))

  BBSRC

  1/04/16 → 31/03/19

  Project: Research

  • Steroid Biosynthesis 100%
  • Metabolic Pathway 50%
  • Enzyme Substrate 50%
  • Gene Knockout 50%
  • Hormone Synthesis 50%

• Androgens: unlocking the key drivers of male health and wellbeing

  Smith, L. (Principal Investigator) & Morton, N. (Co-investigator)

  MRC

  1/01/16 → 2/01/21

  Project: Research

  • Androgen Receptor 100%
  • Sertoli Cell 73%
  • Interstitial Cell 72%
  • Leydig Cell 68%
  • Spermiogenesis 66%

• Integrating systems Biology adn transgenic technologies to unlock the secrets of sertoli cell development and function

  Smith, L. (Principal Investigator) & Freeman, T. (Co-investigator)

  BBSRC

  1/11/12 → 31/10/15

  Project: Research

  • Testes 100%
  • Sertoli Cell 92%
  • Interstitial Cell 75%
  • Leydig Cell 51%
  • Dynamics 50%