Modelling the Influence of RKIP on the ERK Signalling Pathway Using the Stochastic Process Algebra PEPA

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper examines the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signalling pathway [5] through modelling in a Markovian process algebra, PEPA [11]. Two models of the system are presented, a reagent-centric view and a pathway-centric view. The models capture functionality at the level of subpathway, rather than at a molecular level. Each model affords a different perspective of the pathway and analysis. We demonstrate the two models to be formally equivalent using the timing-aware bisimulation defined over PEPA models and discuss the biological significance.
Original languageEnglish
Title of host publicationTransactions on Computational Systems Biology VII
EditorsCorrado Priami, Anna Ingolfsdottir, Bud Mishra, Hanne Riis Nielson
PublisherSpringer-Verlag GmbH
Pages1-23
Number of pages23
ISBN (Electronic)978-3-540-48839-2
ISBN (Print)978-3-540-48837-8
DOIs
Publication statusPublished - 2006

Publication series

NameLecture Notes in Computer Science
PublisherSpringer Berlin / Heidelberg
Volume4230
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

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