Modelling trafficking of proteins within the mammalian cell using Bio-PEPA

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Bio-PEPA, a process algebra developed from PEPA is used to model a process occurring in mammalian cells whereby the Src oncoprotein is trafficked between different parts of the cell. Src is associated with cell movement and adhesion between cells which is linked to tumour formation. A useful model of the protein’s behaviour can provide predictions for new experimental hypotheses which may improve our understanding, and in time, lead to new therapies for cancer. The aim is to assess the suitability of Bio-PEPA for more detailed modelling of Src trafficking than that of a previous simpler Bio-PEPA model.
Original languageEnglish
Title of host publicationComputational Methods in Systems Biology
Subtitle of host publication10th International Conference, CMSB 2012, London, UK, October 3-5, 2012. Proceedings
EditorsDavid Gilbert, Monika Heiner
PublisherSpringer-Verlag GmbH
Pages374-377
Number of pages4
ISBN (Electronic)978-3-642-33636-2
ISBN (Print)978-3-642-33635-5
DOIs
Publication statusPublished - 2012

Publication series

NameLecture Notes in Computer Science
PublisherSpringer Berlin / Heidelberg
Volume7605
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

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