Abstract / Description of output
Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.
Original language | English |
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Pages (from-to) | Unit 9.13 |
Journal | Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] |
Volume | Chapter 9 |
DOIs | |
Publication status | Published - 2002 |