Models of amyotrophic lateral sclerosis

Mandy Jackson, Raquelli Ganel, Jeffrey D Rothstein

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.
Original languageEnglish
Pages (from-to)Unit 9.13
JournalCurrent protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]
VolumeChapter 9
Publication statusPublished - 2002


Dive into the research topics of 'Models of amyotrophic lateral sclerosis'. Together they form a unique fingerprint.

Cite this