Models of amyotrophic lateral sclerosis

Mandy Jackson; Raquelli Ganel; Jeffrey D Rothstein

doi:10.1002/0471142301.ns0913s20

Models of amyotrophic lateral sclerosis

Mandy Jackson, Raquelli Ganel, Jeffrey D Rothstein

School of Neurological and Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.

Original language	English
Pages (from-to)	Unit 9.13
Journal	Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]
Volume	Chapter 9
DOIs	https://doi.org/10.1002/0471142301.ns0913s20
Publication status	Published - 2002

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title = "Models of amyotrophic lateral sclerosis",

abstract = "Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.",

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AU - Rothstein, Jeffrey D

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AB - Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.

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DO - 10.1002/0471142301.ns0913s20

M3 - Article

C2 - 18428572

SN - 1934-8576

VL - Chapter 9

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JO - Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]

JF - Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]

ER -

Models of amyotrophic lateral sclerosis

Abstract

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