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We describe the formation of self-assembling nanoscale fibrillar aggregates from a hybrid system comprising a short polypeptide conjugated to the fluorophore fluorene. The fibrils are typically unbranched, similar to 7 nm in diameter, and many microns in length. A range of techniques are used to demonstrate that the spectroscopic nature of the fluorophore is significantly altered in the fibrillar environment. Time-resolved fluorescence spectroscopy reveals changes in the guest fluorophore, consistent with energy migration and excimer formation within the fibrils. We thus demonstrate the use of self-assembling peptides to drive the assembly of a guest moiety, in which novel characteristics are observed as a consequence. We suggest that this method could be used to drive the assembly of a wide range of guests, offering the development of a variety of useful, smart nanomaterials that are able to self-assemble in a controllable and robust fashion.
|Number of pages||5|
|Journal||Journal of the American Chemical Society|
|Publication status||Published - 23 Apr 2008|
- PI-STACKED POLYMER
- AMYLOID FIBRILS
- SUPRAMOLECULAR HYDROGELS
- CONJUGATED POLYMERS
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- 1 Finished
Edinbugrh Soft Matter and Statistical Physics Programme Grant Renewal
Cates, M., Poon, W., Ackland, G., Clegg, P., Evans, M., MacPhee, C. & Marenduzzo, D.
1/10/07 → 31/03/12