Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms

Jonine D Figueroa; Stella Koutros; Joanne S Colt; Manolis Kogevinas; Montserrat Garcia-Closas; Francisco X Real; Melissa C Friesen; Dalsu Baris; Patricia Stewart; Molly Schwenn; Alison Johnson; Margaret R Karagas; Karla R Armenti; Lee E Moore; Alan Schned; Petra Lenz; Ludmila Prokunina-Olsson; A Rouf Banday; Ashley Paquin; Kris Ylaya; Joon-Yong Chung; Stephen M Hewitt; Michael L Nickerson; Adonina Tardón; Consol Serra; Alfredo Carrato; Reina García-Closas; Josep Lloreta; Núria Malats; Joseph F Fraumeni Jr; Stephen J Chanock; Nilanjan Chatterjee; Nathaniel Rothman; Debra T Silverman

doi:10.1093/jnci/djv223

Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms

Jonine D Figueroa, Stella Koutros, Joanne S Colt, Manolis Kogevinas, Montserrat Garcia-Closas, Francisco X Real, Melissa C Friesen, Dalsu Baris, Patricia Stewart, Molly Schwenn, Alison Johnson, Margaret R Karagas, Karla R Armenti, Lee E Moore, Alan Schned, Petra Lenz, Ludmila Prokunina-Olsson, A Rouf Banday, Ashley Paquin, Kris YlayaJoon-Yong Chung, Stephen M Hewitt, Michael L Nickerson, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina García-Closas, Josep Lloreta, Núria Malats, Joseph F Fraumeni Jr, Stephen J Chanock, Nilanjan Chatterjee, Nathaniel Rothman, Debra T Silverman

Research output: Contribution to journal › Article › peer-review

Abstract

Few studies have demonstrated gene/environment interactions in cancer research. Using data on high-risk occupations for 2258 case patients and 2410 control patients from two bladder cancer studies, we observed that three of 16 known or candidate bladder cancer susceptibility variants displayed statistically significant and consistent evidence of additive interactions; specifically, the GSTM1 deletion polymorphism (P_interaction ≤ .001), rs11892031 (UGT1A, P_interaction = .01), and rs798766 (TMEM129-TACC3-FGFR3, P_interaction= .03). There was limited evidence for multiplicative interactions. When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, P_interaction= .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression. All statistical tests were two-sided. The interaction we observed for rs798766 (TMEM129-TACC3-FGFR3) with specific exposure to straight metalworking fluids illustrates the value of integrating germline genetic variation, environmental exposures, and tumor marker data to provide insight into the mechanisms of bladder carcinogenesis.

Original language	English
Article number	djv223
Number of pages	5
Journal	Journal of the National Cancer Institute (JNCI)
Volume	107
Issue number	11
Early online date	14 Sep 2015
DOIs	https://doi.org/10.1093/jnci/djv223
Publication status	Published - Nov 2015

Keywords

Adult
Aged
Female
Gene Deletion
Gene-Environment Interaction
Genetic Predisposition to Disease
Germ-Line Mutation
Glucuronosyltransferase
Glutathione Transferase
Humans
Male
Metallurgy
Microtubule-Associated Proteins
Middle Aged
Occupational Diseases
Occupational Exposure
Polymorphism, Single Nucleotide
Receptor, Fibroblast Growth Factor, Type 3
Risk Factors
Scotland
Surveys and Questionnaires
Ubiquitin-Protein Ligases
Urinary Bladder Neoplasms

Access to Document

10.1093/jnci/djv223

Jonine Figueroa
- Deanery of Molecular, Genetic and Population Health Sciences - UoE Honorary staff
Person: Affiliated Independent Researcher

Cite this

Figueroa, J. D., Koutros, S., Colt, J. S., Kogevinas, M., Garcia-Closas, M., Real, F. X., Friesen, M. C., Baris, D., Stewart, P., Schwenn, M., Johnson, A., Karagas, M. R., Armenti, K. R., Moore, L. E., Schned, A., Lenz, P., Prokunina-Olsson, L., Banday, A. R., Paquin, A., ... Silverman, D. T. (2015). Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms. Journal of the National Cancer Institute (JNCI), 107(11), [djv223]. https://doi.org/10.1093/jnci/djv223

@article{a33d542fb7014e0a93694fd983eeea7a,

title = "Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms",

abstract = "Few studies have demonstrated gene/environment interactions in cancer research. Using data on high-risk occupations for 2258 case patients and 2410 control patients from two bladder cancer studies, we observed that three of 16 known or candidate bladder cancer susceptibility variants displayed statistically significant and consistent evidence of additive interactions; specifically, the GSTM1 deletion polymorphism (Pinteraction ≤ .001), rs11892031 (UGT1A, Pinteraction = .01), and rs798766 (TMEM129-TACC3-FGFR3, Pinteraction = .03). There was limited evidence for multiplicative interactions. When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, Pinteraction = .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression. All statistical tests were two-sided. The interaction we observed for rs798766 (TMEM129-TACC3-FGFR3) with specific exposure to straight metalworking fluids illustrates the value of integrating germline genetic variation, environmental exposures, and tumor marker data to provide insight into the mechanisms of bladder carcinogenesis.",

keywords = "Adult, Aged, Female, Gene Deletion, Gene-Environment Interaction, Genetic Predisposition to Disease, Germ-Line Mutation, Glucuronosyltransferase, Glutathione Transferase, Humans, Male, Metallurgy, Microtubule-Associated Proteins, Middle Aged, Occupational Diseases, Occupational Exposure, Polymorphism, Single Nucleotide, Receptor, Fibroblast Growth Factor, Type 3, Risk Factors, Scotland, Surveys and Questionnaires, Ubiquitin-Protein Ligases, Urinary Bladder Neoplasms",

author = "Figueroa, {Jonine D} and Stella Koutros and Colt, {Joanne S} and Manolis Kogevinas and Montserrat Garcia-Closas and Real, {Francisco X} and Friesen, {Melissa C} and Dalsu Baris and Patricia Stewart and Molly Schwenn and Alison Johnson and Karagas, {Margaret R} and Armenti, {Karla R} and Moore, {Lee E} and Alan Schned and Petra Lenz and Ludmila Prokunina-Olsson and Banday, {A Rouf} and Ashley Paquin and Kris Ylaya and Joon-Yong Chung and Hewitt, {Stephen M} and Nickerson, {Michael L} and Adonina Tard{\'o}n and Consol Serra and Alfredo Carrato and Reina Garc{\'i}a-Closas and Josep Lloreta and N{\'u}ria Malats and {Fraumeni Jr}, {Joseph F} and Chanock, {Stephen J} and Nilanjan Chatterjee and Nathaniel Rothman and Silverman, {Debra T}",

note = "Published by Oxford University Press 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.",

year = "2015",

month = nov,

doi = "10.1093/jnci/djv223",

language = "English",

volume = "107",

journal = "Journal of the National Cancer Institute (JNCI)",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "11",

}

Figueroa, JD, Koutros, S, Colt, JS, Kogevinas, M, Garcia-Closas, M, Real, FX, Friesen, MC, Baris, D, Stewart, P, Schwenn, M, Johnson, A, Karagas, MR, Armenti, KR, Moore, LE, Schned, A, Lenz, P, Prokunina-Olsson, L, Banday, AR, Paquin, A, Ylaya, K, Chung, J-Y, Hewitt, SM, Nickerson, ML, Tardón, A, Serra, C, Carrato, A, García-Closas, R, Lloreta, J, Malats, N, Fraumeni Jr, JF, Chanock, SJ, Chatterjee, N, Rothman, N & Silverman, DT 2015, 'Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms', Journal of the National Cancer Institute (JNCI), vol. 107, no. 11, djv223. https://doi.org/10.1093/jnci/djv223

TY - JOUR

T1 - Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms

AU - Figueroa, Jonine D

AU - Koutros, Stella

AU - Colt, Joanne S

AU - Kogevinas, Manolis

AU - Garcia-Closas, Montserrat

AU - Real, Francisco X

AU - Friesen, Melissa C

AU - Baris, Dalsu

AU - Stewart, Patricia

AU - Schwenn, Molly

AU - Johnson, Alison

AU - Karagas, Margaret R

AU - Armenti, Karla R

AU - Moore, Lee E

AU - Schned, Alan

AU - Lenz, Petra

AU - Prokunina-Olsson, Ludmila

AU - Banday, A Rouf

AU - Paquin, Ashley

AU - Ylaya, Kris

AU - Chung, Joon-Yong

AU - Hewitt, Stephen M

AU - Nickerson, Michael L

AU - Tardón, Adonina

AU - Serra, Consol

AU - Carrato, Alfredo

AU - García-Closas, Reina

AU - Lloreta, Josep

AU - Malats, Núria

AU - Fraumeni Jr, Joseph F

AU - Chanock, Stephen J

AU - Chatterjee, Nilanjan

AU - Rothman, Nathaniel

AU - Silverman, Debra T

N1 - Published by Oxford University Press 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

PY - 2015/11

Y1 - 2015/11

N2 - Few studies have demonstrated gene/environment interactions in cancer research. Using data on high-risk occupations for 2258 case patients and 2410 control patients from two bladder cancer studies, we observed that three of 16 known or candidate bladder cancer susceptibility variants displayed statistically significant and consistent evidence of additive interactions; specifically, the GSTM1 deletion polymorphism (Pinteraction ≤ .001), rs11892031 (UGT1A, Pinteraction = .01), and rs798766 (TMEM129-TACC3-FGFR3, Pinteraction = .03). There was limited evidence for multiplicative interactions. When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, Pinteraction = .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression. All statistical tests were two-sided. The interaction we observed for rs798766 (TMEM129-TACC3-FGFR3) with specific exposure to straight metalworking fluids illustrates the value of integrating germline genetic variation, environmental exposures, and tumor marker data to provide insight into the mechanisms of bladder carcinogenesis.

AB - Few studies have demonstrated gene/environment interactions in cancer research. Using data on high-risk occupations for 2258 case patients and 2410 control patients from two bladder cancer studies, we observed that three of 16 known or candidate bladder cancer susceptibility variants displayed statistically significant and consistent evidence of additive interactions; specifically, the GSTM1 deletion polymorphism (Pinteraction ≤ .001), rs11892031 (UGT1A, Pinteraction = .01), and rs798766 (TMEM129-TACC3-FGFR3, Pinteraction = .03). There was limited evidence for multiplicative interactions. When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, Pinteraction = .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression. All statistical tests were two-sided. The interaction we observed for rs798766 (TMEM129-TACC3-FGFR3) with specific exposure to straight metalworking fluids illustrates the value of integrating germline genetic variation, environmental exposures, and tumor marker data to provide insight into the mechanisms of bladder carcinogenesis.

KW - Adult

KW - Aged

KW - Female

KW - Gene Deletion

KW - Gene-Environment Interaction

KW - Genetic Predisposition to Disease

KW - Germ-Line Mutation

KW - Glucuronosyltransferase

KW - Glutathione Transferase

KW - Humans

KW - Male

KW - Metallurgy

KW - Microtubule-Associated Proteins

KW - Middle Aged

KW - Occupational Diseases

KW - Occupational Exposure

KW - Polymorphism, Single Nucleotide

KW - Receptor, Fibroblast Growth Factor, Type 3

KW - Risk Factors

KW - Scotland

KW - Surveys and Questionnaires

KW - Ubiquitin-Protein Ligases

KW - Urinary Bladder Neoplasms

U2 - 10.1093/jnci/djv223

DO - 10.1093/jnci/djv223

M3 - Article

C2 - 26374428

VL - 107

JO - Journal of the National Cancer Institute (JNCI)

JF - Journal of the National Cancer Institute (JNCI)

SN - 0027-8874

IS - 11

M1 - djv223

ER -

Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms

Abstract

Keywords

Access to Document

Fingerprint

Profiles

Jonine Figueroa

Cite this